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Adult Peak Pruritus NRS Efficacy Results

In the treatment of adults with uncontrolled moderate-to-severe atopic dermatitis

Rapid itch relief after the first dose (as measured at Week 2)
sustained at 1 year1

Significant itch results in 3 pivotal trials2

CHRONOS 18+ YEARS
≥4-POINT REDUCTION IN PEAK
PRURITUS NRS
(secondary endpoint)1,3,a-c
  • At Week 16 in CHRONOS, 59% of adults treated with DUPIXENT + TCS (n=102) achieved a significant
    itch     reduction vs 20% with placebo + TCS (n=299; secondary endpoint; P<0.0001)2,3,c

Significant itch reduction was also demonstrated with DUPIXENT in monotherapy trials (secondary endpoint)2,4,a,b

41%

of adults treated with DUPIXENT (n=213) achieved ≥4-point reduction in Peak
Pruritus NRS vs 12% with placebo at Week 16 in SOLO 1 (n=212; P<0.001)

36%

of adults treated with DUPIXENT (n=225) achieved ≥4-point reduction in Peak
Pruritus NRS vs 10% with placebo at Week 16 in SOLO 2 (n=221; P<0.001)

Itch data from post hoc analysis5

POOLED SOLO 1 and SOLO 2
18+ YEARS
MEAN CHANGE IN DAILY PEAK PRURITUS NRS AT DAY 15
(post hoc analysis)5
Limitations of analysis:
  • The prespecified itch endpoint in SOLO 1 and SOLO 2 used weekly averaged Peak Pruritus NRS; this post hoc analysis is based on
    daily Peak Pruritus NRS5
  • Definitive conclusions cannot be made as this daily Peak Pruritus analysis (compared with weekly averaged analysis) was post hoc
    and was not statistically powered in these trials5

LSM, least squares mean.

aIn the primary analyses of the efficacy endpoints, subjects who received rescue treatment or with missing data were considered nonresponders.1

bFull Analysis Set includes all subjects randomized.2

cIn CHRONOS, as needed, subjects received topical calcineurin inhibitors for problem areas only, such as the face, neck, and intertriginous and genital areas.1

dWeek 52 data were limited to patients completing 52 weeks as of the cutoff date.1,3

Explore more pruritus NRS efficacy results

VIEW ADOLESCENT
(12 TO 17 YEARS) DATA VIEW INFANT TO PRESCHOOLER
(6 MONTHS TO 5 YEARS) DATA VIEW CHILD
(6 TO 11 YEARS) DATA VIEW AD PATIENTS (12+ years)
WITH HAND AND/OR FOOT
INVOLVEMENT DATA

Pruritus NRS assesses the average itch intensity over the previous 24 hours6

It is a patient-reported measure that uses a 0- to 10-point scale, with which patients are asked:

“On a scale of 0 to 10, how would you rate your itch overall (on average) during the previous 24 hours?”

0 - None

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10 - The Worst
Imaginable

A reduction of at least 4 points in Peak Pruritus NRS from baseline is a clinically meaningful change.2

READY TO PRESCRIBE DUPIXENT?

DOSAGE AND ADMINISTRATION