since initial FDA approval in AD2,a

Globally, ≈593,000 patients
treated
with DUPIXENT
worldwide across
5
indications1,b,c

a FDA approved since 2017 for adults, 2019 for adolescents (aged 12-17 years), 2020 for children (aged 6-11 years), and
2022 for infants to preschoolers (aged 6 months to 5 years) with uncontrolled moderate-to-severe atopic dermatitis.2

b The worldwide patient number is largely comprised of patients treated with DUPIXENT from 10 countries (Canada, China,
France, Germany, Italy, Japan, the Netherlands, Spain, UK, and US) and the rest of the world comprising ≈10% of this
worldwide patient number. Data through January 2023.

c ≈323,000 US AD patients have filled at least 1 DUPIXENT prescription based on IQVIA National Source of Business (NSOB)
data as of December 2022.

Adults, aged 18+ years

CLINICAL TRIAL RESULTS IN ADULTS AND TRIAL DESIGNS


Currently taking DUPIXENT

I needed a long-term option. My arms were constantly itching. Topical Rxs didn't help. DUPIXENT does.

Real patient
being treated
with DUPIXENT.
Individual results
may vary
.

My story

I’ve been seeing specialists for my moderate-to-severe atopic dermatitis since I was 6 years old. It was uncontrolled on topical Rx therapies. Itching was the worst, but since DUPIXENT, it’s more under control. My skin has noticeably cleared up.

My signs and symptoms

  • Flare-ups started as red patches of itchy skin
  • Red patches would transition into more white, discolored patches that were still itchy
  • I would get patches all over my body and my skin would crack and bleed

My treatment and goals

  • I tried a number of different holistic remedies
  • Prescription allergy medications and topical corticosteroids
  • Treatments worked for a while, but they stopped working—I needed an option that I could take continuously and would last

Currently taking DUPIXENT

I tried topical Rxs and experienced
little relief until DUPIXENT. Now less
itch and clearer skin.

Real patient
being treated
with DUPIXENT.
Individual results
may vary.

My story

I was treated by a pediatrician starting at age 5 and later by a dermatologist. When they both ran out of ideas for my uncontrolled moderate-to-severe atopic dermatitis, I was referred to an allergist.

My signs and symptoms

  • Persistent itch and cracking, peeling skin that would blister and ooze
  • Lesions made it difficult for me to swim and perform musical theatre in costume
  • My itch felt like a constant sunburn

My treatment and goals

  • Oral and topical prescription steroids were not enough to help address the itch-scratch cycle
  • I also tried immunosuppressants, UVB treatment 3 times a week, and bleach baths with no success
  • I wanted itch relief—lasting change was my goal

Currently taking DUPIXENT

I was always scratching my face as a baby and have had itchy skin since. With DUPIXENT, I finally feel a difference.

Real patient being treated
with DUPIXENT.
Individual results
may vary.

My story

I was 3 years old when my pediatrician diagnosed me with moderate-to-severe atopic dermatitis. It was uncontrolled on topical Rx therapies ever since and my biggest issue was itching. It’s hard to manage the constant itch!

My signs and symptoms

  • Itchy skin and redness on ankles, back, elbows, feet, hands, knees, torso, and face
  • Skin irritation affected me as a collegiate track runner
  • Itch felt like bugs crawling on my skin and sometimes burning like fire

My treatment and goals

  • Doctors prescribed oral and topical steroids throughout my life
  • Steroids would work temporarily, but my skin would get even worse between treatment courses
  • I challenged my doctors to find something else, something to help relieve the constant itch

Adolescents, aged 12-17 years

CLINICAL TRIAL RESULTS IN ADOLESCENTS AND TRIAL DESIGN


Currently taking DUPIXENT – started in 2020

Topical Rxs weren't enough. With DUPIXENT, his rashes faded, even his feet are looking great!

-Tyler's parents

Real patient
being treated
with DUPIXENT.
Individual results
may vary.

Our story

Tyler has struggled to find control for his moderate-to-severe atopic dermatitis since infancy. Before DUPIXENT, despite using topical Rx therapies, nonstop itching and flares defined his childhood. We wanted his skin to get better with another treatment option.

His signs and symptoms

  • Itching throughout the day
  • Extremely dry, scaly skin with severe rashes—sensitive areas such as his feet were a real problem
  • He had oozing and crusting skin

His treatment and goals

  • Topical prescription therapies worked for awhile, but they stopped working and were damaging to his skin
  • Chlorine baths and wet wraps were also ineffective
  • We had to find another treatment that was appropriate for long-term use

Currently taking DUPIXENT – started in 2019

We tried topical Rxs to clear her skin, but they were not enough. DUPIXENT made a difference.

-Ore's parents

Real patient
being treated
with DUPIXENT.
Individual results
may vary.

Our story

We went from dermatologist to dermatologist since she was a child. Finally, a dermatologist prescribed DUPIXENT for her uncontrolled moderate-to-severe atopic dermatitis. Now Ore can focus less on how to manage her skin.

Her signs and symptoms

  • Constant itching along with dry patches
  • Suffers from comorbid asthma currently managed with asthma medication

Her treatment and goals

  • Creams, moisturizers, phototherapy, bleach baths, and more
  • Diet change to help manage the sores and itching
  • Topical prescription treatments would work for awhile, but were not enough
  • We wanted to break the cycle of topical Rxs and spend less time managing her skin

Children, aged 6-11 years

CLINICAL TRIAL RESULTS IN CHILDREN AND TRIAL DESIGN


Currently taking DUPIXENT

Before DUPIXENT, Harper's hands were a big problem. Topical Rxs just weren't enough.
-Harper's parents

Real patient
being treated
with DUPIXENT.
Individual results
may vary.

Our story

After struggling with moderate-to-severe atopic dermatitis since early childhood, Harper was referred to a specialist by her primary care doctor when topical prescription therapies were not enough. We saw an allergist and a dermatologist. Now on DUPIXENT, Harper has less itching.

Her signs and symptoms

  • Constant burning and itching that never went away
  • Scratching throughout the night
  • Puffy swollen eyes during a flare
  • Her fingers and toes would bleed regularly

Her treatment and goals

  • Treatments from oral and topical prescriptions to bleach baths and light therapy—all were unsuccessful
  • We needed a treatment that could help reduce her itch and clear her skin

WATCH REAL PATIENTS'
STORIES WITH DUPIXENT