Identifying Patients

When topical Rx therapies are not enough, consider DUPIXENT for your patients with uncontrolled moderate-to-severe atopic dermatitis

Which of your patients 6+ years of age may be appropriate for DUPIXENT?

Signs your patients with
uncontrolled
moderate-to-severe atopic
dermatitis may be
appropriate for DUPIXENT



Have tried a variety of topical prescription therapies for atopic dermatitis and are still uncontrolled

  • Suffer from inadequate control of pruritus
  • Have ≥10% of their body covered with lesions and/or may involve problem areas such as the face, hands, and feet1
  • Have moderate-to-severe erythema and moderate-to-severe papulation/infiltration (IGA 3 or 4)2

See below for examples of patients with uncontrolled moderate-to-severe atopic dermatitis who might be appropriate for DUPIXENT.

Struggling with steroid cycles

l'll try anything to heal my skin,
but I never succeed. I always end
up with another cycle of steroids.

All images are of
actual patients.
All stories are
inspired by people who suffer from
atopic dermatitis.

His signs and symptoms

  • His signs generally appear on his legs, neck, upper chest, and back
  • Concerned that customers at the pharmacy think they may catch an "infection" from him
  • Frustrated that he can’t find sustained relief despite trying countless treatment approaches

His treatment and goals

  • Has tried a variety of treatments including antihistamines, multiple potent topical prescription treatments, phototherapy, bleach baths, oatmeal baths, wet wraps, and dietary changes, but nothing provides sustained control
  • The cycling through treatments is becoming too much to handle
  • Wants a treatment that will have a lasting impact on his atopic dermatitis

Worried about her worsening moderate-to-severe atopic dermatitis symptoms

It’s hard enough being a teenager. But it
feels like one big cruel joke when you
throw in the cracking, peeling, red skin.

All images are of
actual patients.
All stories are
inspired by people who suffer from
atopic dermatitis.

Her signs and symptoms

  • Her signs generally appear on her arms, legs, and feet
  • Constantly itching, and her lesion coverage has increased from 10% to 16% in the last year
  • Worried about how she’ll be able to conceal her lesions for an upcoming pool party

Her treatment and goals

  • Has tried a variety of therapies, including potent topical prescription treatments, and has remained uncontrolled
  • Cannot maintain clear skin for long periods of time
  • Her mom is worried that Whitney is running out of treatment options

Visible lesions and frequent itching

Every day was a struggle for him when it
came to his atopic dermatitis, but I felt
there was nothing I could do.

All images are of
actual patients.
All stories are
inspired by people who suffer from
atopic dermatitis.

His signs and symptoms

  • Frequently scratching his lesions, although he knows he shouldn’t
  • Feels everyone makes fun of the way his skin looks

His treatment and goals

  • Has tried topical prescription medications, over-the-counter medications, and dietary changes
  • His parents are struggling to find a treatment that can help reduce the severity of his lesions

Battling intense, persistent itch

My scaly, scarred, itchy dry skin has
me scratching all through the day
and the night.

All images are of
actual patients.
All stories are
inspired by people who suffer from
atopic dermatitis.

Her signs and symptoms

  • Her affected areas are extensive, with lesions covering 55% of her body
  • Her clothes, her sheets, her soap, her detergent, her diet, exercising, the sun—everything makes her itch. And traveling for work makes it even harder to manage it
  • Worried about how she will conceal her skin

Her treatment and goals

  • Relentless in her pursuit of relief, she has worked with several doctors and tried multiple treatments—including potent topical prescription treatments and alternative approaches—and remained uncontrolled
  • Wants more than anything else to lessen her intense itching and achieve clearer skin

Finding it hard to hide her skin

My atopic dermatitis only covers a few
parts of my body—unfortunately, it is
always my hands, wrists, ankles, and neck.

All images are of
actual patients.
All stories are
inspired by people
who suffer from
atopic dermatitis.

Her signs and symptoms

  • Suffers from uncontrolled disease on 12% of her body
  • Her affected areas are minimal, but very visible
  • Has to explain to the parents and children at day care that her condition is not contagious

Her treatment and goals

  • Has tried multiple treatments, including potent topical prescription treatments
  • Wet wraps lessen the redness of her skin, but not the itching, and the process is time-consuming
  • Heidi wants a treatment that helps clear her very visible problem areas

Fighting a losing battle with intense itch

I don’t want to scratch, but not scratching is impossible. My skin ends up paying the price.

All images are of
actual patients.
All stories are
inspired by people who suffer from
atopic dermatitis.

His signs and symptoms

  • Dry, scaly, and red skin that itches incessantly
  • Experiences significant disease across his arms and trunk
  • Concerned about his hockey equipment exacerbating his signs and symptoms

His treatment and goals

  • Recently tried several dietary changes, increased water intake, and tried out new soaps and moisturizers—but they haven’t lessened his itch
  • Has tried a variety of prescription therapies, including potent topical prescription treatments, and has remained uncontrolled
  • Eddie wants to control his persistent itch

References:

  1. Boguniewicz M, Alexis AF, Beck LA, et al. Expert perspectives on management of moderate-to-severe atopic dermatitis: a multidisciplinary consensus addressing current and emerging therapies. J Allergy Clin Immunol Pract. 2017;5(6):1519-1531.
  2. Data on file, Regeneron Pharmaceuticals, Inc.

Important Safety
Information and Indication

CONTRAINDICATION: DUPIXENT is contraindicated in patients with known hypersensitivity to dupilumab or any of its excipients.

WARNINGS AND PRECAUTIONS

Hypersensitivity: Hypersensitivity reactions, including generalized urticaria, rash, erythema nodosum, anaphylaxis and serum sickness or serum sickness-like reactions, were reported in <1% of subjects who received DUPIXENT in clinical trials. If a clinically significant hypersensitivity reaction occurs, institute appropriate therapy and discontinue DUPIXENT.

Conjunctivitis and Keratitis: Conjunctivitis and keratitis occurred more frequently in atopic dermatitis subjects who received DUPIXENT. Conjunctivitis was the most frequently reported eye disorder. Most subjects with conjunctivitis or keratitis recovered or were recovering during the treatment period. Advise patients to report new onset or worsening eye symptoms to their healthcare provider.

Reduction of Corticosteroid Dosage: Do not discontinue systemic, topical or inhaled corticosteroids abruptly upon initiation with DUPIXENT. Reductions in corticosteroid dose, if appropriate, should be gradual and performed under the direct supervision of a physician. Reduction in corticosteroid dose may be associated with systemic withdrawal symptoms and/or unmask conditions previously suppressed by systemic corticosteroid therapy.

Atopic Dermatitis Patients with Comorbid Asthma: Advise patients not to adjust or stop their asthma treatments without consultation with their physicians.

Parasitic (Helminth) Infections: It is unknown if DUPIXENT will influence the immune response against helminth infections. Treat patients with pre-existing helminth infections before initiating therapy with DUPIXENT. If patients become infected while receiving treatment with DUPIXENT and do not respond to anti-helminth treatment, discontinue treatment with DUPIXENT until the infection resolves.

ADVERSE REACTIONS: The most common adverse reactions (incidence ≥1% at Week 16) in adult patients with atopic dermatitis are injection site reactions, conjunctivitis, blepharitis, oral herpes, keratitis, eye pruritus, other herpes simplex virus infection, and dry eye. The safety profile in children and adolescents through Week 16 was similar to that of adults with atopic dermatitis. In an open-label extension study, the long-term safety profile of DUPIXENT in adolescents and children observed through Week 52 was consistent with that seen in adults with atopic dermatitis.

DRUG INTERACTIONS: Avoid use of live vaccines in patients treated with DUPIXENT.

USE IN SPECIFIC POPULATIONS

  • Pregnancy: There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to DUPIXENT during pregnancy. Healthcare providers and patients may call 1-877-311-8972 or go to https://mothertobaby.org/ongoing-study/dupixent/ to enroll in or obtain information about the registry. Available data from case reports and case series with DUPIXENT use in pregnant women have not identified a drug-associated risk of major birth defects, miscarriage or adverse maternal or fetal outcomes. Human IgG antibodies are known to cross the placental barrier; therefore, DUPIXENT may be transmitted from the mother to the developing fetus.
  • Lactation: There are no data on the presence of DUPIXENT in human milk, the effects on the breastfed infant, or the effects on milk production. Maternal IgG is known to be present in human milk. The developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for DUPIXENT and any potential adverse effects on the breastfed child from DUPIXENT or from the underlying maternal condition.

Please see accompanying full Prescribing Information.

Indication

DUPIXENT is indicated for the treatment of patients aged 6 years and older with moderate-to-severe atopic dermatitis whose disease is not adequately controlled with topical prescription therapies or when those therapies are not advisable. DUPIXENT can be used with or without topical corticosteroids.