Visible results with DUPIXENT

In DUPIXENT clinical trials including adolescents, the primary endpoint was the change from baseline to Week 16 in the proportion of subjects with an Investigator’s Global Assessment (IGA) of 0 (clear) or 1 (almost clear) and a ≥2-point improvement.

Actual 12-year-old patient in the phase 3 adolescent DUPIXENT trial. Patient had a baseline IGA of 4 and EASI of 31. Individual results may vary.

Patient 1: Adolescent patient achieved a 2-point improvement in IGA

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A clinical responder was defined as a patient achieving IGA 0 or 1 and at least a 2-point improvement from baseline.1

  • This adolescent patient did not meet the primary endpoint in the clinical trial based on their IGA score at Week 16

Significant skin clearance was demonstrated in adolescents (primary endpoint; P<0.001)1-3,a

Efficacy Results of DUPIXENT at Week 16b
DUPIXENT
(n=82)c
PLACEBO
(n=85)
Achieved clear or almost‑clear skin (IGA 0 or 1) 24% 2%

aResponder was defined as a subject with an IGA 0 or 1 (clear or almost clear) and a reduction of ≥2 points on a 0‑4 scale at Week 16 (primary efficacy outcome).

bFull Analysis Set includes all subjects randomized.

cAdolescents ≥60 kg received DUPIXENT 300 mg Q2W after a 600 mg loading dose, and adolescents <60 kg received 200 mg Q2W after a 400 mg loading dose.1

IGA assesses the overall severity of the clinical signs of atopic dermatitis3

A 0- to 4-point scoring system of the overall severity of atopic dermatitis skin lesions3


4

Severe
Disease

Severe erythema and severe
papulation/infiltration

3

Moderate
Disease

Moderate erythema and moderate
papulation/infiltration

2

Mild
Disease

Mild erythema and mild
papulation/infiltration

1

Almost
Clear

Just perceptible erythema, and
just perceptible papulation/infiltration

0

Clear
 

No inflammatory signs of atopic dermatitis

A clinical responder was defined as a patient achieving IGA 0 or 1 and at least a 2-point improvement from baseline1

IGA, Investigator's Global Assessment.
Example representation of IGA scoring. Not an actual patient.