Reduction in itch after first dose (as measured at Week 3)

6 MONTHS TO 5 YEARS

Significant itch reduction
(≥4-point improvement in
Worst Scratch/Itch NRS)
with DUPIXENT + TCS at
Week 16 in AD-1539
(secondary endpoint)1‑3,a,b

Definitive conclusions cannot be made for time points earlier than Week 16 as those data were not multiplicity-controlled and P value was nominal.

View the Infants to
Preschoolers Study Design View the Infants to
Preschoolers Safety Profile

aFull Analysis Set includes all subjects randomized.1

bIn the primary analyses of the efficacy endpoints, subjects who received rescue treatment or with missing data were considered nonresponders.1

EXPLORE MORE PRURITUS
NRS EFFICACY RESULTS

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ADULT DATA VIEW ADOLESCENT
(12 TO 17 YEARS) DATA VIEW CHILD
(6 TO 11 YEARS) DATA

Pruritis NRS assesses the average itch intensity over the previous 24 hours4

It is a patient-reported measure that uses a 0- to 10-point scale, with which patients are asked:

“On a scale of 0 to 10, how would you rate your itch overall (on average) during the previous 24 hours?”

0

None

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The Worst Imaginable

A reduction of at least 4 points in pruritis NRS from baseline is a clinically meaningful change.2

Dosage and
administration
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