Clearer skin after the
first dose (as measured
at Week 2)1,2
(secondary endpoint)1-3,a,b
Definitive conclusions cannot be made for time points earlier than Week 16
as those data were not multiplicity controlled
and P value was
nominal.
EASI, Eczema Area and Severity Index; EASI-75, ≥75% improvement in lesion extent and severity; Q4W, once every 4 weeks; TCS, topical corticosteroids.
aFull Analysis Set includes all subjects randomized.1
bIn the primary analyses of the efficacy endpoints, subjects who received rescue treatment or with missing data were considered nonresponders.1
Explore more severity index results
Measuring the extent and severity of lesional signs of atopic dermatitis
EASI combines the severity of the signs of eczema and the extent of skin involvement.4
The severity of each of
4 eczema signs is
assessed on a scale of
0 to 34
The EASI scoring system uses a defined process to grade the severity of the signs of eczema (erythema, edema/papulation, excoriation, and lichenification) and the extent to which the patient is affected.
The extent of lesions in each body region is evaluated based on the percentage of involvement and is given a value between 0 and 6. Each body region value is then weighted by a corresponding multiplier; lower extremities are weighted more while head and neck are weighted the least.4
Each region gets a total region score:
Severity Score x
Area Score x Multiplier
= Region Score
The final EASI score is the sum of
all 4 region scores. The composite
score, on a scale from 0 to 72,
determines the severity of the
signs of eczema and the extent to
which the patient is affected.4,c
An improvement of at least 75% in lesion extent and severity (EASI-75) from baseline is a clinically meaningful change.1
cIn patients <8 years of age, the multipliers for the head and neck are 0.2, the trunk is 0.3, the upper extremities are 0.2, and the lower extremities are 0.3.
In patients ≥8 years of age, the multipliers for the head and neck are 0.1, the trunk is 0.3, the upper extremities are 0.2, and the lower extremities are 0.4.4
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