≥75% improvement in hand lesion extent and severity (HECSI-75) at Week 16
(secondary endpoint)

Explore safety in adults
and adolescents

ADULT (18+ years of age) ADOLESCENT (12-17 years
of age)

HECSI is a clinical scale that combines severity of the clinical signs of hand eczema and the extent of skin involvement. The severity of 6 clinical signs of hand eczema in 5 areas of the hands is assessed on a scale from 0 to 3 in each of 5 areas of the hands. The extent of lesions in each area of the hands is evaluated based on a percentage involvement of surface area and is given a value between 0 and 4.

An extent and severity score for each of the 5 areas of the hands ranges from 0 to 72 points and is calculated as shown below:

Clinical signs
  • Erythema
  • Induration/papulation
  • Vesicles
  • Fissuring
  • Scaling
  • Edema

Multiply
severity
by
extent
for each
clinical sign

 
Severity score
No skin changes = 0
Mild disease = 1
Moderate disease = 2
Severe disease = 3
X
Extent score (Surface area
involvement)
0% = 0
1% to 25% = 1
26% to 50% = 2
51% to 75% = 3
76% to 100% = 4

Severity multiplied by extent results in a score between 0 and 12 for each clinical sign. The scores for each of the 6 clinical signs are added, resulting in a score between 0 and 72 for each of the 5 areas of the hands.

Areas of the hand (a separate area score from 0 to 72 for each)
Fingertips
Fingers
(Excluding fingertips)
Palm of the hands
Back of the hands
Wrists

Total HECSI score is the sum of all 5 area scores and ranges from 0 to 360 points. Overall hand eczema extent and severity based on HECSI score is as follows:

Clear (0)

Almost clear (1-16)

Moderate (17-37)

Severe (38-116)

Very severe (≥117)

Dosage and
administration

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