Significant Itch Relief

A total of 251 adolescent patients in Trial 6 (16-week trial) with moderate-to-severe atopic dermatitis not adequately controlled with topical prescription treatments were randomized to DUPIXENT or placebo. Adolescents ≥60 kg received DUPIXENT 300 mg Q2W following a 600 mg loading dose, while adolescents <60 kg received 200 mg Q2W following a 400 mg loading dose. An endpoint included the reduction in itch as defined by ≥4-point improvement in the Peak Pruritus NRS at Week 16.1,2

Significant Itch Relief for Uncontrolled Moderate-to-Severe Atopic Dermatitis

12-17 years

Significant itch reduction (Peak Pruritus NRS) at Week 16 with DUPIXENT in Trial 6 (secondary endpoint)1-3,a,b

The safety and efficacy of DUPIXENT were generally consistent between adolescents and adults1

  1. FAS includes all subjects randomized.
  2. Subjects who received rescue treatment or with missing data were considered nonresponders (59% and 21% in the placebo and DUPIXENT arms, respectively).

Pruritus NRS assesses the average itch intensity over the previous 24 hours4

A patient-reported measure that uses a 0- to 10-point scale, with which patients are asked4:


“On a scale of 0 to 10, how would you rate your itch overall (on average) during the previous 24 hours?”

None
The Worst
Imaginable

A reduction of at least 4 points in pruritus NRS from baseline is a clinically meaningful change.1

EASI, Eczema Area and Severity Index; NRS, numerical rating scale.

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References:
  1. DUPIXENT Prescribing Information.
  2. Data on file, Regeneron Pharmaceuticals, Inc.
  3. Simpson EL, Paller AS, Siegfried EC, et al. Efficacy and safety of dupilumab in adolescents with uncontrolled moderate to severe atopic dermatitis: a phase 3 randomized clinical trial [published online November 6, 2019]. JAMA Dermatol. doi: 10.1001/jamadermatol.2019.3336
  4. Phan NQ, Blome C, Fritz F, et al. Assessment of pruritus intensity: prospective study on validity and reliability of the visual analogue scale, numerical rating scale and verbal rating scale in 471 patients with chronic pruritus. Acta Derm Venereol. 2012;92(5):502-507.