Itch results demonstrated in an adolescent pivotal trial1
Adolescents ≥60 kg received DUPIXENT 300 mg Q2W after a 600 mg loading dose, and adolescents <60 kg received 200 mg Q2W after a400 mg loading dose.1
Change in Daily Peak Pruritus NRS in a post hoc analysis of AD-15264
Limitations of analysis:
- The prespecified itch endpoint in AD-1526 used weekly averaged Peak Pruritus NRS; this post hoc analysis is based on daily Peak Pruritus NRS4
- Definitive conclusions cannot be made as this daily Peak Pruritus analysis (compared with weekly averaged analysis) was post hoc and was not statistically powered in this trial4
LSM, least squares mean.
aFull Analysis Set includes all subjects randomized.
bIn the primary analyses of the efficacy endpoints, subjects who received rescue treatment or with missing data were considered nonresponders (59% and 21% in the placebo and DUPIXENT arms, respectively).
cP<0.0001 vs placebo.
Pruritus NRS assesses the average itch intensity over the previous 24 hours5
It is a patient-reported measure that uses a 0- to 10-point scale, with which patients are asked:
“On a scale of 0 to 10, how would you rate your itch overall (on average) during the previous 24 hours?”