Randomized

PRIME (N=151)
DUPIXENT
300 mg Q2W after
600 mg loading
dose for 24 weeks (n=75) Matched placebo for 24 weeks
(n=76)

PRIME2 (N=160)
DUPIXENT
300 mg Q2W after
600 mg loading
dose for 24 weeks (n=78) Matched placebo for 24 weeks
(n=82)
Study population

Adults (>18 years) with:
  • Severe pruritus (WI‑NRS ≥7 on a scale of 0 to 10)
  • Greater than or equal to 20 PN lesions
  • Disease that was not adequately controlled with topical prescription therapies or when those therapies were not advisable

Over half did not have a history of atopy (defined as having a medical history of AD, allergic rhinitis/rhinoconjunctivitis, asthma, or food allergy).
Primary endpoints1,2

PRIME (N=151)
Week 24
  • Proportion of subjects with ≥4‑point improvement in WI‑NRS
PRIME2 (N=160)
Week 12
  • Proportion of subjects with ≥4‑point improvement in WI‑NRS
Key secondary endpoints1,2

Week 24
  • Proportion of subjects with IGA PN‑S 0 or 1 (the equivalent of 0-5 nodules)
  • Proportion of subjects who achieved both ≥4-point improvement in WI‑NRS and IGA PN‑S of 0 or 1 at Week 24
  • Proportion of subjects with ≥4‑point improvement in WI‑NRS (PRIME2 only)
Among subjects enrolled in the US (n=43), 55% were White, 36% were Black, and 7% were Asian.1

AD, atopic dermatitis; IGA PN-S, Investigator’s Global Assessment PN-Stage; Q2W, once every 2 weeks; TCI, topical calcineurin inhibitors; TCS, topical corticosteroids; WI-NRS, Worst Itch Numeric Rating Scale.

See WI‑NRS Results

Dosage and Administration

Thinking about prescribing DUPIXENT? Find the information you need to get started.
Explore administration Options