MOA

DUPIXENT AFFECTS IL-4 AND IL-13 SIGNALING, IMPACTING TWO OF THE SOURCES THAT MEDIATE ALLERGIC AND EOSINOPHILIC INFLAMMATION1

Type 2 inflammation plays an important role in the pathogenesis of asthma1-3


IL-4 and IL-13 activate multiple cell types and induce multiple mediators involved in inflammation—contributing to airflow limitation and increasing the risk of severe exacerbations1-3


IgE
Eosinophils
FeNOa

DUPIXENT blocks the IL-4/IL-13 pathway and decreases markers of Type 2 inflammation, including1,2,4,5:

TOTAL AND ALLERGEN-SPECIFIC IgE
Up to 70% reduction in total IgE from baseline
EOSINOPHILIC LUNG INFLAMMATION
despite the presence of normal or increased blood eosinophil levels
FeNO (a marker of lung inflammation)
Up to 35% reduction from baseline
The mechanism of dupilumab action in asthma has not been established.1
  • a Fractional exhaled nitric oxide (FeNO) has not been established as useful for ruling in or ruling out a diagnosis of asthma; however, FeNO is higher in asthma that is characterized by Type 2 airway inflammation.6

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    References:
  1. DUPIXENT Prescribing Information.
  2. Robinson D, Humbert M, Buhl R, et al. Revisiting type 2-high and type 2-low airway inflammation in asthma: current knowledge and therapeutic implications. Clin Exp Allergy. 2017;47(2):161-175.
  3. Hammad H, Lambrecht BN. Dendritic cells and epithelial cells: linking innate and adaptive immunity in asthma. Nat Rev Immunol. 2008;8(3):193-204.
  4. Castro M, Corren J, Pavord ID, et al. Dupilumab efficacy and safety in moderate-to-severe uncontrolled asthma. N Engl J Med. 2018;378(26):2486-2496.
  5. Ravensberg AJ, Ricciardolo FLM, van Schadewijk A, et al. Eotaxin-2 and eotaxin-3 expression is associated with persistent eosinophilic bronchial inflammation in patients with asthma after allergen challenge. J Allergy Clin Immunol. 2005;115(4):779-785.
  6. Global Initiative for Asthma. Definition, description, and diagnosis of asthma. In: Global Strategy for Asthma Management and Prevention. https://ginasthma.org/. Updated 2018. Accessed February 7, 2019.