DUPIXENT is a medicine that is administered by subcutaneous injection and is intended for use under the guidance of a healthcare provider.1
- Patients may self-inject DUPIXENT—or a caregiver may administer DUPIXENT—after training has been provided by a healthcare provider on proper subcutaneous injection technique using the pre-filled syringe or pen
- It is important to provide proper training to patients and/or caregivers on the preparation and administration of DUPIXENT prior to use
- After administration, advise patients to follow sharps disposal recommendations
- Patients and/or caregivers should read the Instructions for Use prior to injecting
ADULTS (18+) Years
Inadequately Controlled CRSwNP1
Inadequately Controlled CRSwNP1
18+ YEARS
Every 2 weeks
1 pre-filled pen or syringe
NO LOADING DOSE
a 300 mg=2 mL solution.
Two Administration Options for You and Your Patients
Important Administration
Instructions2,3- Patients should read the Instructions for Use prior to injecting
- Administer the subcutaneous injection into the thigh or abdomen, except for the 2 inches (5 cm) around the navel
- The upper arm can also be used if a caregiver administers the injection
- Rotate the injection site with each injection. DO NOT inject DUPIXENT into skin that is tender, damaged, bruised, or scarred
- If a dose is missed, instruct the patient to administer the injection within 7 days from the missed dose and then resume their original schedule. If the missed dose is not administered within 7 days, instruct the patient to wait until the next dose on the original schedule
Pre-filled Pen

Preparation for Use1
Before injection, instruct patients and/or caregivers to remove DUPIXENT from the refrigerator and allow DUPIXENT to reach room temperature without removing the needle cap.
- 45 minutes for the 300 mg/2 mL
pre‑filled syringe or pre-filled pen
Patients and/or caregivers should inspect DUPIXENT for particulate matter and discoloration prior to administration.
- Do not use if the liquid contains visible particulate matter or is discolored or cloudy (other than clear to slightly opalescent, colorless to pale yellow)
Patients and/or caregivers should discard any unused product remaining in the pre‑filled syringe or pre-filled pen in accordance with local requirements.
Storage and Handling1
- DUPIXENT is sterile and preservative‑free. Patients and/or caregivers should discard any unused portion
- Patients and/or caregivers should store DUPIXENT by refrigerating at 36 °F to 46 °F (2 °C to 8 °C) in the original carton to protect from light
- If necessary, DUPIXENT may be kept at room temperature up to 77 °F (25 °C) for a maximum of 14 days. DUPIXENT should not be stored above 77 °F (25 °C). After removal from the refrigerator, DUPIXENT must be used within 14 days or discarded
- DUPIXENT should not be exposed to heat or direct sunlight
- Do NOT freeze. Do NOT shake
- Any unused medicinal product or waste material should be disposed of in accordance with local requirements
