DUPIXENT is a medicine that is administered by subcutaneous injection and is intended for use under the guidance of a healthcare provider.1
  • A patient may self-inject DUPIXENT—or a caregiver may administer DUPIXENT—after training has been provided by a healthcare provider on proper subcutaneous injection technique using the pre-filled syringe or pre-filled pen
  • It is important to provide proper training to patients and/or caregivers on the preparation and administration of DUPIXENT prior to use
  • Advise patients to follow sharps disposal recommendations after administration
  • Patients and/or caregivers should read the Instructions for Use prior to injecting

ADULTS (18+) Years
Inadequately Controlled CRSwNP1


No loading dose

300 mg Q2Wa

1 pre-filled pen or syringe

a 300 mg=2 mL solution.

Two Administration Options for You and Your Patients

Important Administration Instructions1-3

  • Patients should read the Instructions for Use prior to injecting
  • Instruct patients and/or caregivers to administer the subcutaneous injection into the thigh or abdomen, except for the 2 inches (5 cm) around the navel
  • The upper arm can also be used if a caregiver administers the injection
  • It is important to rotate the injection site with each injection. DO NOT inject DUPIXENT into skin that is tender, damaged, bruised, or scarred
  • If a dose is missed, instruct the patient to administer the injection within 7 days from the missed dose and then resume their original schedule. If the missed dose is not administered within 7 days, instruct the patient to wait until the next dose on the original schedule

Preparation for Use1

Before injection, instruct patients and/or caregivers to remove DUPIXENT from the refrigerator and allow DUPIXENT to reach room temperature without removing the needle cap.

  • 45 minutes for the 300 mg/2 mL pre‑filled syringe or pre-filled pen

Patients and/or caregivers should inspect DUPIXENT for particulate matter and discoloration prior to administration.

  • Do not use if the liquid contains visible particulate matter or is discolored or cloudy (other than clear to slightly opalescent, colorless to pale yellow)

Patients and/or caregivers should discard any unused product remaining in the pre‑filled syringe or pre-filled pen in accordance with local requirements.

Storage and Handling1

  • DUPIXENT is sterile and preservative‑free. Patients and/or caregivers should discard any unused portion
  • Patients and/or caregivers should store DUPIXENT by refrigerating at 36​​ °​F to
    46​​ °​F (2​​ °​C to 8 ​​°​C) in the original carton to protect from light
  • If necessary, DUPIXENT may be kept at room temperature up to 77​​ °​F (25 ​​°​C) for a maximum of 14 days. DUPIXENT should not be stored above 77 ​​°​F (25 ​​°​C). After removal from the refrigerator, DUPIXENT must be used within 14 days or discarded
  • DUPIXENT should not be exposed to heat or direct sunlight
  • Do NOT freeze. Do NOT shake
  • Any unused medicinal product or waste material should be disposed of in accordance with local requirements