Up to 87%

of patients with
CRSwNP have
evidence of type 2
inflammation.2

CRSwNP Patients With Type 2 Inflammation Have a Higher Burden of Disease2-7

Loss of sense
of smell2-4

Oral steroid use5
 

Nasal
congestion/
obstruction2-4

History of other
diseases that
are driven in
part by type 2
inflammation4,6,a

Polyp recurrence6,7
 

a Including but not limited to asthma, allergic rhinitis, and/or atopic dermatitis.

Explore Some of the Possible Patient Types Right for DUPIXENT

DUPIXENT was studied in CRSwNP patients with and without prior sino-nasal surgery1

CRSwNP Patient With Co-existing Disease Driven in Part by Type 2 Inflammation

Meet David, 41 Years old, Diagnosed With CRSwNP 8 Years ago

Medical History

  • Reduced sense of smell
  • Nasal congestion and obstruction
  • Nasal irrigation, INCS, and 3 SCS bursts
    in the past year
  • No previous sinus surgeries
  • History of allergic rhinitis

His Evaluation Reveals:

  • SNOT-22 score (0-110): 55
  • NPS (0-8): 5
  • UPSIT score (0-40): 22
  • NC score (0-3): 2

Patient profile is representative and
is not an actual DUPIXENT patient.

“I feel embarrassed of
my worsening nasal
symptoms. It’s been
years since I’ve gone out
with friends and not
worried about a runny
nose, congestion, or
sneezing.”

Patient profile is representative and
is not an actual DUPIXENT patient.

CRSwNP Patient With Recurrence After Prior Sinus Surgery

Meet Robert, 56 Years old, Diagnosed With CRSwNP 12 Years ago

Medical History

  • Uncontrolled CRSwNP with polyp recurrence
  • Underwent sinus surgery 2 years ago
  • Loss of sense of smell and taste with nasal
    congestion and obstruction
  • Nasal irrigation, INCS, and 3 SCS bursts in
    the past year

His Evaluation Reveals:

  • SNOT-22 score (0-110): 55
  • NPS (0-8): 5
  • UPSIT score (0-40): 14
  • NC score (0-3): 3

Patient profile is representative and
is not an actual DUPIXENT patient.

“I just wish I could smell
food again! I had
surgery, but my
symptoms have since
returned.”

Patient profile is representative and
is not an actual DUPIXENT patient.

CRSwNP Patient With Co-existing NSAID-ERD

Meet Rachel, 45 Years old, Diagnosed With CRSwNP 14 Years ago

Medical History

  • Loss of sense of smell
  • Nasal congestion and obstruction
  • Diagnosis of asthma 10 years ago and NSAID-ERD by
    aspirin challenge
  • 2 SCS bursts in the past year for CRSwNP, INCS,
    and high-dose ICS/LABA
  • 3 previous sinus surgeries

Her Evaluation Reveals:

  • NC score (0-3): 3
  • NPS (0-8): 6
  • LMK-CT score (0-24): 18
  • UPSIT score (0-40): 15
  • FEV1: 60% of predicted
  • SNOT-22 score (0-110): 55

Patient profile is representative and
is not an actual DUPIXENT patient.

”I feel helpless with
these breathing issues,
along with the constant
sinus pain, congestion,
and runny nose. I just
can’t get it under
control.”

Patient profile is representative and
is not an actual DUPIXENT patient.

FEV1, forced expiratory volume in 1 second; ICS, inhaled corticosteroid; INCS, intranasal corticosteroid; LABA, long-acting beta agonist; LMK-CT, Lund-Mackay computed tomography; NC, nasal congestion/
obstruction; NPS, nasal polyp score; NSAID-ERD, nonsteroidal anti-inflammatory drug–exacerbated respiratory disease; SCS, systemic corticosteroid; SNOT-22, 22-item Sino-Nasal Outcome Test; UPSIT, University of Pennsylvania Smell Identification Test.


Learn More About the
Efficacy and
Safety
Profile of DUPIXENT
Efficacy and Safety