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DOSAGE AND ADMINISTRATION

A dosing schedule you are familiar with, now in csu:

One dose every 2 weeks after an initial loading dose1

Train patients and/or caregivers on proper administration prior to use.

ONE REGIMEN
IN ADULTS

18+
YEARS

One dosage regimen
in adults regardless
of weight

Initial loading dose:

600 mg
2 x 300 mg
WEIGHT-TIERED
IN ADOLESCENTSa

12 TO 17 YEARS

≥60 kg

600 mg
2 x 300 mg

30 to <60 kg

400 mg
2 x 200 mg

Q2W, once every 2 weeks.

a30 kg is equal to 66 lb; 60 kg is equal to 132 lb.

Available in a single 200 mg or single 300 mg pre-filled pen or pre-filled syringe for subcutaneous injection1

Consider before injecting

DUPIXENT is an injectable medicine that is administered by subcutaneous injection and is intended for use under the guidance of a healthcare provider.1

  • A patient may self-inject DUPIXENT—or a caregiver may administer DUPIXENT—after training has been provided by a healthcare provider on proper subcutaneous injection technique using the pre-filled syringe or pre-filled pen1
    • In children 12 years of age and older, it is recommended that DUPIXENT be administered by or under the supervision of an adult
  • It is important to provide proper training to patients and/or caregivers on the preparation and administration of DUPIXENT prior to use1
  • After administration, advise patients to follow sharps disposal recommendations1
  • Patients and/or caregivers should read all the Instructions for Use—either 200 mg or 300 mg pre-filled pen or pre-filled syringe—prior to injecting1
  • Consider completing all age-appropriate vaccinations as recommended by current immunization guidelines prior to initiating treatment with DUPIXENT1

At-home or in-office administration options

Important administration
instructions1,2

Preparation and administration of DUPIXENT

Preparation and administration of DUPIXENT

  • Patients and/or caregivers should read the Instructions for Use prior to injecting
  • Instruct patients and/or caregivers to administer subcutaneous injection into the thigh or abdomen, except for the 2 inches (5 cm) around the navel
  • The upper arm can also be used if a caregiver administers the injection
  • It is important to rotate the injection site with each injection. DO NOT inject DUPIXENT into skin that is tender, damaged, bruised, or scarred
  • For the initial dose, patients and/or caregivers should administer each DUPIXENT injection at a different injection site
  • In children 12 years of age and older, it is recommended that DUPIXENT be administered by or under the supervision of an adult

See the Instructions for Use for more detailed instructions on the preparation and administration of DUPIXENT.

For supplemental injection training, visit our
Patient Video Injection Support page

Pre-filled Pen

Instructions for Use - 200 mg

Instructions for Use - 300 mg

Pre-filled Syringe

Instructions for Use - 200 mg

Instructions for Use - 300 mg

ADDITIONAL DOSAGE INFORMATION

Before injection, instruct patients and/or caregivers to remove the DUPIXENT pre‑filled pen or syringe from the refrigerator and allow DUPIXENT to reach room temperature without removing the needle cap.

  • 45 minutes for the 300 mg/2 mL pre-filled pen or syringe
  • 30 minutes for the 200 mg/1.14 mL pre-filled pen or syringe

Patients and/or caregivers should not use the pre-filled pen or syringe if the liquid contains visible particulate matter, or is discolored or cloudy (other than clear to slightly opalescent, colorless to pale yellow).

Patients and/or caregivers should discard any unused product remaining in the pre-filled pen or syringe in accordance with local requirements.

For supplemental injection training, visit our
Patient Video Injection Support Page

DUPIXENT is a clear to slightly opalescent, colorless to pale yellow solution available as:

  • Injection: 300 mg/2 mL in a single-dose, pre-filled pen with hidden needle or syringe with needle shield
  • Injection: 200 mg/1.14 mL in a single-dose, pre-filled pen with hidden needle or syringe with needle shield

DUPIXENT is available in cartons containing 2 pre-filled pens or syringes with needle shields. Each 300 mg pre-filled syringe or pre-filled pen delivers 300 mg/2 mL. Each 200 mg pre-filled syringe or pre-filled pen delivers 200 mg/1.14 mL.

  • DUPIXENT is sterile and preservative-free. Patients and/or caregivers should discard any unused portion
  • Patients and/or caregivers should store DUPIXENT by refrigerating between 36 °F to 46 °F (2 °C to 8 °C) in the original carton to protect from light
  • If necessary, pre-filled pens or syringes may be kept at room temperature up to 77 °F (25 °C) for a maximum of 14 days. DUPIXENT should not be stored above 77 °F (25 °C). After removal from the refrigerator, DUPIXENT must be used within 14 days or discarded
  • Do not expose DUPIXENT to heat or direct sunlight
  • Do NOT freeze. Do NOT shake
  • Any unused medicinal product or waste material should be disposed of in accordance with local requirements

CSU, chronic spontaneous urticaria.

DUPIXENT MyWay®

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