DUPIXENT is an injectable medicine that is administered subcutaneously and is intended for use under the guidance of a healthcare provider.1

  • DUPIXENT is administered by subcutaneous injection and is intended for use under the guidance of a healthcare provider1
  • A caregiver or patient 12 years of age and older may inject DUPIXENT after training in subcutaneous injection technique using the pre-filled syringe or pre-filled pen1
  • In children 12 years of age and older, it is recommended that DUPIXENT be given by or under the supervision of an adult1
  • In children 1 year to less than 12 years of age, DUPIXENT should be given by a caregiver1
  • Provide proper training to patients and/or caregivers on the preparation and administration of DUPIXENT prior to use, according to the Instructions for Use1
  • Consider completing all age-appropriate vaccinations as recommended by current immunization guidelines prior to initiating treatment with DUPIXENT1

Weight-based dosing and OPTION TO ADMINISTER at home or in office1

Weight-tiered dosage regimen1

1+ YEAR OF AGE

No loading dose

15 to <30 kg

Every 2 weeks

200 mga

1 pre-filled pen or syringe

30 to <40 kg

Every 2 weeks

300 mgb

1 pre-filled pen or syringe

≥40 kgc

Every week

300 mgb

1 pre-filled pen or syringe

a200 mg=1.14 mL solution.1

b300 mg=2 mL solution.1

cThe recommended dosage of 300 mg QW for pediatric subjects 1 to 11 years of age weighing ≥40 kg is based on modeled pharmacokinetic data to provide comparable exposures to the 300 mg QW dosage in adult and pediatric subjects 12 years of age and older weighing ≥40 kg with EoE.1

Administration options1

Important administration instructions1

  • Patients and/or caregivers should read the Instructions for Use prior to injecting
  • Instruct patients and/or caregivers to administer the subcutaneous injection into the thigh or abdomen, except for the 2 inches (5 cm) around the navel
  • The upper arm can also be used if a caregiver administers the injection
  • It is important to rotate the injection site with each injection. DO NOT inject DUPIXENT into skin that is tender, damaged, bruised, or scarred

See the Instructions for Use for more detailed instructions on the preparation and administration of DUPIXENT

Pre-filled Pen

Instructions for Use - 200 mg Instructions for Use - 300 mg

Pre-filled Syringe

Instructions for Use - 200 mg Instructions for Use - 300 mg

Supplemental Injection Training

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Missed dose information1

  • If a weekly dose is missed, administer the dose as soon as possible, and start a new weekly schedule from the date of the last administered dose
  • If an every other week dose is missed, administer the injection within 7 days from the missed dose and then resume the patient’s original schedule. If the missed dose is not administered within 7 days, wait until the next dose on the original schedule

Preparation for use1

Before injection, instruct patients and/or caregivers to remove DUPIXENT from the refrigerator and allow DUPIXENT to reach room temperature without removing the needle cap.

  • 45 minutes for the 300 mg/2 mL pre‑filled syringe or pre-filled pen
  • 30 minutes for the 200 mg/1.14 mL pre-filled syringe or pre-filled pen

Patients and/or caregivers should inspect DUPIXENT visually for particulate matter and discoloration prior to administration.

  • Do not use if the liquid contains visible particulate matter or is discolored or cloudy (other than clear to slightly opalescent, colorless to pale yellow)

Patients and/or caregivers should discard any unused product remaining in the pre‑filled syringe or pre-filled pen in accordance with local requirements.

Storage and handling1

  • DUPIXENT is sterile and preservative-free. Patients and/or caregivers should discard any unused portion
  • Patients and/or caregivers should store DUPIXENT by refrigerating at 36 °F to 46 °F (2 °C to 8 °C) in the original carton to protect from light
  • If necessary, DUPIXENT may be kept at room temperature up to 77 °F (25 °C) for a maximum of 14 days. DUPIXENT should not be
    stored above 77 °F (25 °C). After removal from the refrigerator, DUPIXENT must be used within 14 days or discarded
  • DUPIXENT should not be exposed to heat or direct sunlight
  • Any unused medicinal product or waste material should be disposed of in accordance with local requirements
  • Do NOT freeze. Do NOT shake

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