EoE KIDS-Part A
Secondary Endpoint
EoE KIDS-Part B
Secondary Endpoint
Not actual patients.
Histologic improvements were observed at Week 16 and Week 521,2
Histologic Remission1,2
(≤6 EOS/HPF peak esophageal
intraepithelial EOS count)
Histologic Response1,2
(<15 EOS/HPF peak esophageal
intraepithelial EOS count)
Results are descriptive in the extended active treatment period at Week 52. Definitive conclusions cannot be made due to limitations associated with extended active treatment design, including lack of comparator arm and decreasing sample size.2
EOS, eosinophil: EOS/HPF, eosinophils per high-power field.
Improvements in EREFS total scores were observed at Weeks 16 and 52 with DUPIXENT1,2
Reduction in EREFS
total scored
Thresholds for clinically meaningful changes in EREFS scores have not been established. Results are descriptive in the extended active treatment period at Week 52. Definitive conclusions cannot be made due to limitations associated with extended active treatment design, including lack of comparator arm and decreasing sample size.2
dReductions indicate improvements in score.2
LSM, least squares mean.
Decrease in the number of days with ≥1 sign or symptom of EoE via LSM change in PESQ-C1,2,e
Definitive conclusions cannot be made. Numerical improvements were observed at Week 16 and maintained for 52 weeks. Results are descriptive at Week 52 due to limitations associated with extended active treatment design, including lack of comparator arm and decreasing sample size.3
eBaseline number of days with EoE symptoms out of a 14-day period was 6.0 days in the DUPIXENT arm, 6.9 days in the placebo arm, and 7.8 days in the placebo to DUPIXENT arm.3
Pediatric EoE Signs/Symptoms Questionnaire-Caregiver (PESQ-C) is a novel questionnaire designed with expert guidance to recognize 8 distinct signs and symptoms of EoE over a 14-day period by caregivers3,6:
Change in body weight for age percentile2,a
Results are descriptive. Definitive conclusions cannot be made due to the exploratory nature of the results at Week 16, and lack of comparator arm and decreasing sample size at Week 52.3
a Body weight for age percentile, standardized by gender and age, is used to assess a child's weight compared to their peers.
LSM, least squares mean.