DO YOU RECOGNIZE SOME OF THESE COMMON
CHALLENGES IN YOUR PATIENTS WITH EoE?
ARE YOUR PATIENTS WITH EoE REALLY FINE?
CLINICAL PRESENTATION
- Symptoms: chest pain and painful swallowing
- Histologic findings: 47 EOS/HPF
- Endoscopic findings: edema, exudates, mild furrows
- Uncontrolled on PPIs
CURRENT CONCERNS
- Patient says she’s feeling fine, but she’s cutting food into tiny pieces
- Hesitates to eat dinner out
- Gets embarrassed that it takes her a long time to eat
EOS/HPF, eosinophils per high-power field; PPI, proton pump inhibitor.
Patient profiles are representative and are not actual DUPIXENT patients.
Dr. Wechsler, MD, MSCI
It's so vital that we get education out there to families, to doctors, to health care providers, to really understand just how different this disease can be for so many.
It’s so vital that we get education out there to families, to doctors, to health care providers, to really understand just how different this disease can be for so many.
IS DILATION ADDRESSING DRIVERS UNDERLYING
EoE INFLAMMATION?
CLINICAL PRESENTATION
- Symptoms: persistent dysphagia (~4 episodes per week)
- Histologic findings: 81 EOS/HPF
- Endoscopic findings: exudates, furrows, rings,
and stricture - 2 emergency room visits and dilation in the past year
- Uncontrolled on PPIs
CURRENT CONCERNS
- Concerned about pain and discomfort of dilations
- Missing work due to a dilation procedure or emergency room visit
- Worried about complications
EOS/HPF, eosinophils per high-power field; PPI, proton pump inhibitor.
Patient profiles are representative and are not actual DUPIXENT patients.
Dr. Wechsler, MD, MSCI
Not everyone’s going to experience a complete resolution of symptoms. Some people are going to have ongoing symptoms. Sometimes it’s related to their EoE. Sometimes they might need another dilation. Sometimes they have another condition that seems like it’s related to EoE. So everyone’s patient experience is going to be different.
IS YOUR PATIENT IMPROVING OR WORSENING?
CLINICAL PRESENTATION
- Symptoms: dysphagia (~2 episodes per week)
- Histologic findings: 59 EOS/HPF
- Endoscopic findings: edema, exudates, furrows, and
mild rings - Uncontrolled on high-dose PPIs and elimination diet
- Concomitant asthma
CURRENT CONCERNS
- Fear of choking while eating lunch with friends at school
- Patient’s mother is concerned about long-term uncontrolled symptoms
- Maintaining elimination diet
EOS/HPF, eosinophils per high-power field; PPI, proton pump inhibitor.
Patient profiles are representative and are not actual DUPIXENT patients.
ARE YOUR YOUNG PATIENTS SHOWING
SIGNS OF INFLAMMATION?
CLINICAL PRESENTATION
- Symptoms: abdominal pain, vomiting (~1-2 episodes per week), and new onset of mild dysphagia
- Histologic findings: 43 EOS/HPF
- Endoscopic findings: edema, exudates, mild furrows, and mild rings
- Uncontrolled on high-dose PPIs
CURRENT CONCERNS
- Mealtimes are a struggle due to the risk of gagging or throwing up
- Caregiver is concerned about new symptoms and worsening disease
- Unable to identify a particular food trigger
EOS/HPF, eosinophils per high-power field; PPI, proton pump inhibitor.
Patient profiles are representative and are not actual DUPIXENT patients.
Dr. Wechsler MD, MSCI
One of the challenges I find with patients, actually, and especially taking care of kids is really understanding what’s actually going on with them. And we talked about before the idea of Talk Back, the idea that I hear something and I repeat it back, and I actually do that a lot with symptoms because I think it can be very challenging to communicate what’s going on with you or make sure that there’s a clear understanding of the disease.
IS SHE MORE THAN JUST A PICKY EATER?
CLINICAL PRESENTATION
- Symptoms: food refusal, vomiting, and regurgitation
- Histologic findings: 37 EOS/HPF
- Endoscopic findings: edema, exudates, and mild furrows
- Uncontrolled on high-dose PPIs and elimination diet
CURRENT CONCERNS
- Difficulty eating upsets the patient at mealtimes
- Her caregiver is concerned about the impacts of long-term uncontrolled symptoms
- Maintaining elimination diet
EOS/HPF, eosinophils per high-power field; PPI, proton pump inhibitor.
Patient profiles are representative and are not actual DUPIXENT patients.
Managing eoe requires a comprehensive approach across3:
Clinical
Frequency and severity
of symptoms
HISTOLOGIC
Changes in eosinophilic
inflammation
ENDOSCOPIC
Visible changes in the
esophagus
DUPIXENT MyWay®
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histologic,
and
endoscopic endpoints4-6