Dosing & Administration

DUPIXENT can be administered at home

DUPIXENT is intended for use under the guidance of a healthcare provider. A patient may self-inject DUPIXENT after training in subcutaneous injection technique using the pre-filled syringe. Provide proper training to patients and/or caregivers on the preparation and administration of DUPIXENT prior to use according to the Instructions for Use.

DUPIXENT can be administered in the office under the guidance of a healthcare provider if the patient is not an appropriate candidate for self-administration.

Recommended dosing

INTIAL DOSE 2 WEEKS LATER EVERY-OTHER-WEEK DOSING 400 mg (two 200 mga pre-filled syringes) 200 mg pre-filled syringe OR 600 mg (two 300 mgb pre-filled syringes) 300 mg pre-filled syringe

OCS-dependent asthma:

  • Initial dose is 600 mg (two 300 mg pre-filled syringes) followed 2 weeks later by every-other-week dosing of 300 mg pre-filled syringe

In patients with comorbid moderate-to-severe atopic dermatitis for which DUPIXENT is indicated:

  • Initial dose is 600 mg (two 300 mg pre-filled syringes) followed 2 weeks later by every-other-week dosing of 300 mg pre-filled syringe
  • DUPIXENT is also indicated for the treatment of adult patients with moderate-to-severe atopic dermatitis whose disease is not adequately controlled with topical prescription therapies or when those therapies are not advisable. DUPIXENT can be used with or without topical corticosteroids

Important administration instructions

  • Patients should read the Instructions for Use prior to injecting
  • Instruct patients and/or caregivers to administer subcutaneous injection into the thigh or abdomen, except for the 2 inches (5 cm) around the navel
  • The upper arm can also be used if a caregiver administers the injection
  • For the initial 400 or 600 mg dose in moderate-to-severe asthma patients, patients and/or caregivers should administer each of the two DUPIXENT 200 mg (for 400 mg initial dose) or 300 mg (for 600 mg initial dose) injections at a different injection site
  • It is important to rotate the injection site with each injection. DO NOT inject DUPIXENT into skin that is tender, damaged, bruised, or scarred
  • If a dose is missed, instruct the patient to administer the injection within 7 days from the missed dose and then resume the patient's original schedule. If the missed dose is not administered within 7 days, instruct the patient to wait until the next dose on the original schedule
  • a200 mg=1.14 mL solution.
  • b300 mg=2 mL solution.

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Reference: DUPIXENT Prescribing Information. October 2018.