PATIENT TYPES

A PATH TO ASTHMA CONTROL FOR DIFFERENT PATIENT TYPES

Explore how DUPIXENT may help control symptoms in different types of patients.

Patients Enrolled Had Elevations in Multiple Biomarkers, Including Eosinophils, IgE, and FeNO1

Examples of patients with an eosinophilic phenotype or with OCS-dependent asthma.

Patient profiles are representative and are not actual DUPIXENT patients.

EOS 155 cells/µL

IgE 380 IU/mL

  • 2 severe exacerbations in the past year
  • Compromised lung function: 70% FEV1 % predicted
  • Diagnosed with asthma as a child
  • Positive skin test to a perennial aeroallergen
  • Triple therapy: ICS/LABA + LTRA
Explore exacerbation data

EOS 320 cells/µL

IgE 430 IU/mL

FeNO 40 ppb

  • 2 severe exacerbations in the past year
  • Compromised lung function: 65% FEV1 % predicted
  • Diagnosed with adult-onset asthma at age 28
  • Lack of asthma control
  • Triple therapy: High-dose ICS/LABA + LAMA
Explore lung function data
  • 2 severe exacerbations in the past year
  • Compromised lung function: 58% FEV1 % predicted
  • Diagnosed with adult-onset asthma at age 23
  • Lack of asthma control
  • Multiple courses of OCS treatment over 6 months, potentially leading to2:
    • Symptoms of anxiety and depression
    • Weight gain
    • Type 2 diabetes
    • Vision problems
  • Triple therapy: High-dose ICS/LABA + LTRA
EXPLORE OCS-DEPENDENT DATA

LABA, long-acting beta agonist; LAMA, long-acting muscarinic antagonist; LTRA, leukotriene receptor antagonist.

REQUIRE NO BIOMARKER
TESTING for ocs-dependent
asthma patients for
dupixent3



Get more information on
the 3 clinical trials

See the full study designs

References:

  1. DUPIXENT Prescribing Information.
  2. Price DB, Trudo F, Voorham J, et al. Adverse outcomes from initiation of systemic corticosteroids for asthma: long-term observational study. J Asthma Allergy. 2018;11:193-204.
  3. UnitedHealthcare. UnitedHealthcare Pharmacy Clinical Pharmacy Programs. 2019.

Important Safety
Information and Indication

CONTRAINDICATION: DUPIXENT is contraindicated in patients with known hypersensitivity to dupilumab or any of its excipients.

WARNINGS AND PRECAUTIONS

Hypersensitivity: Hypersensitivity reactions, including generalized urticaria, rash, erythema nodosum, anaphylaxis and serum sickness or serum sickness-like reactions, were reported in <1% of subjects who received DUPIXENT in clinical trials. If a clinically significant hypersensitivity reaction occurs, institute appropriate therapy and discontinue DUPIXENT.

Eosinophilic Conditions: Patients being treated for asthma may present with serious systemic eosinophilia sometimes presenting with clinical features of eosinophilic pneumonia or vasculitis consistent with eosinophilic granulomatosis with polyangiitis (EGPA), conditions which are often treated with systemic corticosteroid therapy. These events may be associated with the reduction of oral corticosteroid therapy. Physicians should be alert to vasculitic rash, worsening pulmonary symptoms, cardiac complications, and/or neuropathy presenting in their patients with eosinophilia. Cases of eosinophilic pneumonia were reported in adult patients who participated in the asthma development program and cases of vasculitis consistent with EGPA have been reported with DUPIXENT in adult patients who participated in the asthma development program as well as in adult patients with co-morbid asthma in the chronic rhinosinusitis with nasal polyposis development program. A causal association between DUPIXENT and these conditions has not been established.

Acute Asthma Symptoms or Deteriorating Disease: Do not use DUPIXENT to treat acute asthma symptoms, acute exacerbations, acute bronchospasm or status asthmaticus. Patients should seek medical advice if their asthma remains uncontrolled or worsens after initiation of DUPIXENT.

Reduction of Corticosteroid Dosage: Do not discontinue systemic, topical, or inhaled corticosteroids abruptly upon initiation with DUPIXENT. Reductions in corticosteroid dose, if appropriate, should be gradual and performed under the direct supervision of a physician. Reduction in corticosteroid dose may be associated with systemic withdrawal symptoms and/or unmask conditions previously suppressed by systemic corticosteroid therapy.

Parasitic (Helminth) Infections: It is unknown if DUPIXENT will influence the immune response against helminth infections. Treat patients with pre-existing helminth infections before initiating therapy with DUPIXENT. If patients become infected while receiving treatment with DUPIXENT and do not respond to anti-helminth treatment, discontinue treatment with DUPIXENT until the infection resolves.

ADVERSE REACTIONS: The most common adverse reactions (incidence ≥1%) in patients with asthma are injection site reactions, oropharyngeal pain, and eosinophilia.

DRUG INTERACTIONS: Avoid use of live vaccines in patients treated with DUPIXENT.

USE IN SPECIFIC POPULATIONS

  • Pregnancy: There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to DUPIXENT during pregnancy. Healthcare providers and patients may call 1-877-311-8972 or go to https://mothertobaby.org/ongoing-study/dupixent/ to enroll in or obtain information about the registry. Available data from case reports and case series with DUPIXENT use in pregnant women have not identified a drug-associated risk of major birth defects, miscarriage or adverse maternal or fetal outcomes. Human IgG antibodies are known to cross the placental barrier; therefore, DUPIXENT may be transmitted from the mother to the developing fetus.
  • Lactation: There are no data on the presence of DUPIXENT in human milk, the effects on the breastfed infant, or the effects on milk production. Maternal IgG is known to be present in human milk. The developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for DUPIXENT and any potential adverse effects on the breastfed child from DUPIXENT or from the underlying maternal condition.

Please see accompanying full Prescribing Information.


Indication

DUPIXENT is indicated as an add-on maintenance treatment in patients with moderate-to-severe asthma aged 12 years and older with an eosinophilic phenotype or with oral corticosteroid dependent asthma. Limitation of Use: DUPIXENT is not indicated for the relief of acute bronchospasm or status asthmaticus.