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SINUS OPACIFICATION

SIGNIFICANT IMPROVEMENT IN SINUS OPACIFICATION
WITH DUPIXENT AT week 24 AND WEEK 52

Not an actual DUPIXENT patient.

SIGNIFICANT IMPROVEMENT IN SINUS OPACIFICATION
WITH DUPIXENT AT week 24 AND WEEK 52

Not an actual DUPIXENT patient.

DUPIXENT significantly decreased sinus opacification as measured by LMK-CT score at Week 521,2

aAt Week 24 (secondary endpoint), LMK-CT score reduction of 7.38 from a baseline score of 17.50 with DUPIXENT (n=33) vs
reduction of 1.93 from a baseline score of 18.45 with placebo (n=29); LSM difference between DUPIXENT and placebo: -5.45 (95%
CI: -7.48, -3.43) (P<0.0001).1,2

bAt Week 52 (primary endpoint), LMK-CT score reduction of 9.17 from a baseline score of 17.50 with DUPIXENT (n=33) vs reduction
of 1.81 from a baseline score of 18.45 with placebo (n=29); LSM difference between DUPIXENT and placebo: -7.36 (95% CI: -9.38,
-5.35) (P<0.0001).1,2

Lund-Mackay computed tomography (LMK-CT) score: Reader assesses a CT scan of each sinus and assigns a score from 0 (normal) to 2 (complete opacification), or, for the ostiomeatal complex, 0 (not opacified) or 2 (opacified). For all sinus systems, the total score is the sum from both the right and left sinuses, with a maximum of 24. Lower score indicates improvement (reduced opacification).1,2

CT, computed tomography; LSM, least squares mean.

Explore Results in
Nasal Congestion,
Nasal Polyp
Score,
and Sense of Smell

NASAL CONGESTION NASAL POLYP SCORE SENSE OF SMELL Study design and safety data