Skip to main content
Identifying Patients

ALLERGIC FUNGAL RHINOSINUSITIS (AFRS):
A DISEASE DRIVEN IN PART BY TYPE 2 INFLAMMATION THAT CAN
CAUSE SEVERE PATIENT BURDEN1,2

Not an actual DUPIXENT patient.

ALLERGIC FUNGAL RHINOSINUSITIS (AFRS):
A DISEASE DRIVEN IN PART BY TYPE 2 INFLAMMATION THAT CAN
CAUSE SEVERE PATIENT BURDEN1,2

Not an actual DUPIXENT patient.

AFRS IS A UNIQUE AND DISTINCT SUBTYPE OF CRS,
DRIVEN IN PART BY TYPE 2 INFLAMMATION3,4
The prevalence of AFRS can vary throughout the US, with higher
prevalence in warm, humid regions1,5
DISEASE OVERVIEW4

This is not an exhaustive list of all CRS subtypes.4

Chronic Rhinosinusitis with Nasal Polyps: DUPIXENT is indicated as an add-on maintenance treatment in adult and pediatric patients aged 12 years and older with inadequately controlled chronic rhinosinusitis with nasal polyps (CRSwNP).

Allergic Fungal Rhinosinusitis: DUPIXENT is indicated for the treatment of adult and pediatric patients aged 6 years and older with allergic fungal rhinosinusitis (AFRS) who have a history of sino-nasal surgery.

AFRS is characterized by IgE-mediated hypersensitivity to fungal elements and the accumulation of eosinophilic mucin within the sinuses.1

DISTINCT
FEATURES

Peanut-Buttery Mucus:
Thick, sticky, green-to-black mucus6

Fungal Species:
Positive fungal stain, most commonly species of Aspergillus or Curvularia6-8

Total Serum IgE:
Markedly elevated total IgE levels (>500 IU /mL), often exceeding 1000 IU/mL6,9

AFRS progression can lead to severe structural consequences, including bone erosion10

CURRENT TREATMENT
UNMET NEED

Surgery

Sinus surgery is aimed at eliminating fungal debris and opening sinuses.13
However, recurrence rates with surgery can be high:

38%
of postsurgical recurrence
occurs within 1 year7

Steroids

Systemic steroids are used to reduce inflammation. Cumulative long-term use of systemic steroids can cause negative consequences, including1:

  • Hyperglycemia
  • Infection
  • Poor wound healing
  • Avascular necrosis
  • Increased ocular pressure

This is not an exhaustive list of all potential side effects associated with systemic steroids.1

Other treatments

For antifungal agents, there is insufficient evidence to recommend for or against antifungal therapy in AFRS, according to the International Consensus Statement on Allergy and Rhinology.14

AERD, aspirin-exacerbated respiratory disease; CRS, chronic rhinosinusitis.

ARE YOUR PATIENTS READY FOR A BIOLOGIC TO
HELP MAINTAIN CONTROL OF THEIR AFRS?
See surgery and steroid reduction data in Efficacy section

MEET JAMES 27 years old

clinical profile
  • Newly diagnosed with AFRS following sino-nasal surgery; had previously been prescribed systemic steroids to address symptoms
  • Presenting with thick, sticky, peanut butter–like mucus
  • AFRS symptoms include nasal congestion with facial pain

AFRS PATIENTS LIKE JAMES COULD BE IDEAL FOR A
TREATMENT THAT TARGETS TWO OF THE KEY AND CENTRAL
DRIVERS OF TYPE 2 INFLAMMATION6,8,15,*

*The mechanism of dupilumab action has not been definitively established.15

Explore DUPIXENT Efficacy for Appropriate AFRS Patients

Learn moreStudy design and
safety data