Injection site reactionsa
SINUS-24 and SINUS-52
(24-week safety pool)
Q2W + INCS n=440 n (%)
Q2W + INCS
n=440
n (%)
28 (6%)
7 (2%)
14 (3%)
7 (2%)
6 (1%)
5 (1%)
5 (1%)
n=282
n (%)
12 (4%)
2 (1%)
5 (2%)
2 (1%)
0 (<1%)
1 (<1%)
1 (<1%)
aInjection site reactions cluster includes injection site reaction, pain, bruising, and swelling.
bConjunctivitis cluster includes conjunctivitis, allergic conjunctivitis, bacterial conjunctivitis, viral conjunctivitis, giant papillary conjunctivitis, eye irritation, and eye inflammation.
INCS, intranasal corticosteroid; Q2W, once every 2 weeks.
The safety profile of DUPIXENT Q2W through Week 52 was generally consistent with the safety profile observed at Week 24.1
In subjects with CRSwNP, the frequency of conjunctivitis was 2% in the DUPIXENT group compared with 1% in the placebo group in the 24-week safety pool; these subjects recovered. There were no cases of keratitis reported in the CRSwNP development program.1
In SINUS-52 (52 weeks), the frequency of conjunctivitis was 3% in the DUPIXENT group compared with 1% in the placebo group; all of these subjects recovered.1
The proportion of subjects who discontinued treatment due to adverse
events was 2% with DUPIXENT and 5% with placebo1
Explore the
Study Designs
Administration