Significantly Improved Nasal Congestion/Obstruction Score at
Weeks 24 (Coprimary Endpoint) and 52 (Key Secondary Endpoint) in Patients Who Were Uncontrolled on SOC1,2,a

SINUS-52

CHANGE IN NC SCORE THROUGH WEEK 52

51%

IMPROVEMENT AT WEEK 24 with DUPIXENT Q2W + INCS (n=295, pooled DUPIXENT arms) (-1.25 from a baseline score of 2.46) vs 16% improvement with placebo + INCS (n=153) (-0.38 from a baseline score of 2.38) (LSM difference: -0.87 [95% CI: -1.03, -0.71]) in SINUS-521

  • NC SCORE IMPROVED AS EARLY AS WEEK 4 IN SINUS-52: -0.52 with DUPIXENT Q2W + INCS (n=295, pooled DUPIXENT arms) vs -0.16 with placebo + INCS (n=153) (LSM difference: -0.37 [95% CI: -0.46, -0.27])1,2
59%

IMPROVEMENT AT WEEK 24 with DUPIXENT Q2W + INCS (-1.34 from a baseline score of 2.26) vs 18% improvement with placebo + INCS (-0.45 from a baseline score of 2.45) (LSM difference: -0.89 [95% CI: -1.07, -0.71]) in SINUS-241

a All patients in the placebo and DUPIXENT arms were on a background therapy of INCS, mometasone furoate nasal spray.1

Nasal congestion/obstruction (NC) score (range 0 to 3): reduced score indicates improvement.

see scs use + sino-nasal surgery results
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