Indication DUPIXENT is indicated as an add-on maintenance treatment in adult patients with inadequately controlled chronic rhinosinusitis with nasal polyposis (CRSwNP).As an add-on maintenance treatment in adult patients with inadequately controlled chronic rhinosinusitis with nasal polyposis (CRSwNP).
DUPIXENT is the first biologic approved in CRSwNP that targets the inflammation underlying the disease—so your patients can achieve and maintain control

Take a different path to
CRSwNP CONTROL

Targets underlying inflammation, so your
patients can achieve and maintain control1,2

71% IMPROVEMENT
IN UPSIT SCORE2,a UP TO 59% IMPROVEMENT
IN NC SCORE1,b 76% REDUCTION
IN SCS USE OR NEED FOR
SINO-NASAL SURGERY1,c

Identify CRSwNP
patients appropriate
for DUPIXENT

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DUPIXENT is a dual
inhibitor of IL-4 and IL-13
signaling and is not an
immunosuppressant1

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The DUPIXENT 300 mg Pre-filled Pen is
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  • aAt Week 52 (Trial 2: secondary endpoint) with DUPIXENT 300 mg Q2W + INCS (n=150) (9.53 from a baseline score of 13.46) vs 6% worsening with placebo + INCS (n=153) (-0.77 from a baseline score of 13.78) (LSM difference: 10.30 [95% CI: 8.50, 12.10]).2
  • bAt Week 24 (Trial 1: primary endpoint) with DUPIXENT Q2W + INCS (-1.34 from a baseline score of 2.26) vs 18% improvement with placebo + INCS (-0.45 from a baseline score of 2.45) (LSM difference: -0.89 [95% CI: -1.07, -0.71]).1
  • cIndividually, SCS reduction and need for sino-nasal surgery were not multiplicity-adjusted endpoints.
  • CRSwNP, chronic rhinosinusitis with nasal polyposis; INCS, intranasal corticosteroids; LSM, least squares mean; NC, nasal congestion/obstruction; Q2W, once every 2 weeks; SCS, systemic corticosteroid; UPSIT, University of Pennsylvania Smell Identification Test.
Dosing & Administration
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References:

  1. DUPIXENT Prescribing Information.
  2. Data on file, Sanofi US, 2018.