EREFS is an endoscopic scoring system for inflammatory and remodeling features of EoE including edema, rings, exudates, furrows, and stricture. Each feature is graded on its severity and is assigned an associated value. The EREFS total score (range: 0 to 18) is the composite value of the proximal and distal esophageal regions with each region scored from 0 to 9.4-8

A higher score indicates greater disease severity. However, thresholds for clinically meaningful changes in EREFS scores have not been established.1,3