DUPIXENT has a unique mechanism of action. It is the only dual inhibitor of IL-4 and IL-13 signaling, two of the key sources of local and systemic type 2 inflammation in asthma. GINA guidelines define type 2 inflammation as an immune response identified in part by 1 or more biomarkers. The mechanism of dupilumab action has not been definitively established.1-6

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DUPIXENT TARGETS IL-4 AND
IL-13 SIGNALING