^aIncluding Th2, Th17, and Th22 cells, eosinophils, and basophils.

^bType 2 cytokines (such as IL-4, IL-13, and IL-31) may also be produced by other immune cells, such as ILC2.^13,14

^cIL-4 acts on both type I and type Il receptors to mediate type 2 inflammation.²