EREFS IS USED TO DETERMINE SEVERITY OF 5 ENDOSCOPIC FINDINGS IN EOE:
EDEMA, RINGS, EXUDATES, FURROWS, AND STRICTURE3
EREFS CLASSIFICATION4,5
EDEMA
(Grades 0-2)
Grade 1
RINGS
(Grades 0-3)
Grade 3
EXUDATES
(Grades 0-2)
Grade 2
FURROWS
(Grades 0-2)
Grade 2
STRICTURE
(Grades 0-2)
Grade 1
Scores from the proximal and distal regions range from 0 to 9.3
The EREFS total score is the sum of those 2 regions (range 0-18).6
EXAMPLES OF ENDOSCOPIC IMAGES FROM THE ESOPHAGUS DEMONSTRATE MULTIPLE
WAYS TO ACHIEVE THE SAME SCORE3,7,8
EREFS SCORE OF 3 OUT OF 9a
E1, R1, E0, F1, S0
E1, R0, E0, F2, S0
EREFS SCORE OF 5 OUT OF 9a
E1, R2, E0, F1, S1
E1, R2, E1, F1, S0
a Endoscopic images are from a region of the esophagus in different patients and are not composite EREFS total scores. Endoscopic images are for reference only.
Adapted by permission from BMJ Publishing Group Limited. Gut, Hirano I et al, vol. 62, pages 489-495 (2013). Adapted with permission from Wolters Kluwer Health, Inc.: Kia L, Hirano I. Advances in the endoscopic evaluation of eosinophilic esophagitis, Curr Opin Gastroenterol, vol. 32(4), pages 325-331. https://journals.lww.com/co-gastroenterology/ Reprinted from J Allergy Clin lmmunol Pract, vol. 6(5), Steinbach EC et al, Eosinophilic esophagitis and the eosinophilic gastrointestinal diseases: approach to diagnosis and management, pages 1483-1495 (2018), with permission from Elsevier.