REAL STORIES

What if your disease had an impact on the things you love to do in life—baking, exercising, or gardening? These ambassadors found that their chronic rhinosinusitis with nasal polyposis (CRSwNP) could not be well controlled with their current prescription treatments.

THEN DUPIXENT WAS RECOMMENDED BY THEIR DOCTOR. HEAR THEIR STORIES.

MEET OUR AMBASSADORS

MARK’S STORY

Oral steroids, antibiotics, surgery—Mark had tried just about everything to treat his nasal polyps.
A conversation with his doctor led to some independent research, which revealed that DUPIXENT could
be the key to managing his symptoms.

A COLLABORATIVE EXPERIENCE

MARK:

I struggled with nasal polyps for years. I had congestion, trouble breathing, and even lost my sense of smell.

I had two surgeries during my treatment for nasal polyps. During that time I tried oral steroids and antibiotics to keep the polyps under control. But my nasal polyps kept coming back.

That’s when my doctor brought up DUPIXENT as a treatment option.

DR. SHER:

I see many patients who suffer from CRSwNP like Mark.

When a nasal polyp patient comes into my office and they’ve failed other treatment measures, I’ll bring up DUPIXENT.

I tell them that DUPIXENT is an add-on biologic treatment that specifically targets underlying inflammation.

MARK:

I listened carefully to what my doctor said about DUPIXENT being a biologic treatment, and I liked what I was hearing.

But I was cautiously optimistic.

I had tried so many things and I was really hoping this could work for me.

DR. SHER:

My patients have similar concerns to Mark and will ask me if DUPIXENT could work for them.

I tell them that we have many other patients with nasal polyps that have been through this treatment regimen and the clinical trials saw positive results.

Patients I’ve treated with DUPIXENT have had their smell improve, experienced less nasal congestion, are breathing better and their nasal polyps have shrunk without needing additional surgery.

But of course, everyone’s experience will be different.

I also always make sure that I talk to my patients about the benefits and risks of treatment.

MARK:

I did some research on my own, thought about it, and decided to give it a try.

MARK:

Before I started DUPIXENT, I told my doctor about all the medical conditions I had and medications I was taking.

My doctor and I talked about the potential benefits and risks of treatment, including the most common side effects such as injection site reactions, and some serious side effects including allergic reactions that can sometimes be severe, eye problems, inflammation of your blood vessels, and joint aches and pain.

DR. SHER:

My patients are often hesitant to try DUPIXENT, and one of the main concerns that I hear is that they’re afraid of using an injectable medication.

DUPIXENT is an injectable medication that is a biologic. It works differently from other medications such as oral steroids.

I explain to my patients that most biologics are given by injection.

MARK

When I learned that DUPIXENT was an injection, that was a little bit worrisome just because I hadn’t ever done an injection before.

My doctor explained that I would be trained on how to properly inject and my wife could also be trained to help with my injections.

In my doctor's office I was given literature about DUPIXENT and how that would work and was referred to DUPIXENT.com.

DR. SHER:

Like Mark’s doctor, I explain to my self-injecting patients that before they start DUPIXENT, we will bring them into the office, and we will train them.

I really want my patients to feel okay with their injections.

In my experience, most patients become comfortable with injecting over time, but everyone’s experience is different.

MARK:

Another concern I had was around cost.

Thankfully my doctor told me about a patient support program called DUPIXENT MyWay®.

They explained that the DUPIXENT MyWay® patient support program could potentially help me reduce the out-of-pocket cost of DUPIXENT with the DUPIXENT MyWay Copay Card.

They can also answer any questions regarding insurance coverage for treatment and help teach patients how to receive and stay on track with DUPIXENT.

DR. SHER:

I feel it is very important to have an open dialogue with my patients.

It’s rewarding for both of us when we find a treatment option that works for them.

MARK:

My doctor was great at keeping me involved in the decision-making process.

It was very much a collaborative experience.

I’m grateful that together, we ultimately made the decision to start treatment with DUPIXENT.

VO:

Important Safety
Information and Indication

Do not use if you are allergic to dupilumab or to any of the ingredients in DUPIXENT®.

Before using DUPIXENT, tell your healthcare provider about all your medical conditions, including if you:

  • have eye problems.
  • have a parasitic (helminth) infection.
  • are scheduled to receive any vaccinations. You should not receive a “live vaccine” right before and during treatment with DUPIXENT.
  • are pregnant or plan to become pregnant. It is not known whether DUPIXENT will harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known whether DUPIXENT passes into your breast milk.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.

Especially tell your healthcare provider if you are taking oral, topical, or inhaled corticosteroid medicines or if you have CRSwNP and asthma and use an asthma medicine. Do not change or stop your corticosteroid medicine or other asthma medicine without talking to your healthcare provider. This may cause other symptoms that were controlled by the corticosteroid medicine or other asthma medicine to come back.

DUPIXENT can cause serious side effects, including:

  • Allergic reactions. DUPIXENT can cause allergic reactions that can sometimes be severe. Stop using DUPIXENT and tell your healthcare provider or get emergency help right away if you get any of the following signs or symptoms: breathing problems or wheezing, swelling of the face, lips, mouth, tongue, or throat, fainting, dizziness, feeling lightheaded, fast pulse, fever, hives, joint pain, general ill feeling, itching, skin rash, swollen lymph nodes, nausea or vomiting, or cramps in your stomach-area.
  • Eye problems. Tell your healthcare provider if you have any new or worsening eye problems, including eye pain or changes in vision, such as blurred vision. Your healthcare provider may send you to an ophthalmologist for an eye exam if needed.
  • Inflammation of your blood vessels. Rarely, this can happen in people with asthma who receive DUPIXENT. This may happen in people who also take a steroid medicine by mouth that is being stopped or the dose is being lowered. It is not known whether this is caused by DUPIXENT. Tell your healthcare provider right away if you have: rash, chest pain, worsening shortness of breath, or a feeling of pins and needles or numbness of your arms or legs, or persistent fever.
  • Joint aches and pain. Some people who use DUPIXENT have had trouble walking or moving due to their joint symptoms, and in some cases needed to be hospitalized. Tell your healthcare provider about any new or worsening joint symptoms. Your healthcare provider may stop DUPIXENT if you develop joint symptoms.

The most common side effects in patients with chronic rhinosinusitis with nasal polyposis include injection site reactions, eye and eyelid inflammation, including redness, swelling, and itching, sometimes with blurred vision, high count of a certain white blood cell (eosinophilia), trouble sleeping (insomnia), toothache, gastritis and joint pain (arthralgia).

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of DUPIXENT. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Use DUPIXENT exactly as prescribed by your healthcare provider. It’s an injection given under the skin (subcutaneous injection). Your healthcare provider will decide if you or your caregiver can inject DUPIXENT. Do not try to prepare and inject DUPIXENT until you or your caregiver have been trained by your healthcare provider.

Please see accompanying full Prescribing Information including Patient Information.

Indication

DUPIXENT is a prescription medicine used with other medicines for the maintenance treatment of chronic rhinosinusitis with nasal polyposis (CRSwNP) in adults whose disease is not controlled. It is not known if DUPIXENT is safe and effective in children with chronic rhinosinusitis with nasal polyposis under 18 years of age.

KATHY'S STORY

Kathy's nasal polyps have been a struggle for years. Struggling to breathe because of them,
she also lost interest in her two favorite hobbies. After numerous treatments, and surgery,
her doctor recommended DUPIXENT.

BATTLING NASAL CONGESTION

Kathy:

Hi, I’m Kathy, and I am definitely not a fan of my uncontrolled nasal polyps. For me, those little growths inside my nose led to big problems! For years, I had been battling nasal congestion. I struggled to breathe out of my nose. My nose would make weird, funny noises sometimes. I was worried my coworkers would get annoyed at my wheezing and stuffiness. I lost interest in two of my favorite hobbies: cooking and gardening. Who wants to spend time preparing a meal or planting flowers you can barely smell?

Living with nasal polyps wore me down. I went through several different treatment options, including surgery.

Finally, one of my doctors recommended DUPIXENT.

KATHY:

Before I started DUPIXENT, I told my doctor about all the medical conditions I had and medications I was taking.

My doctor and I talked about the potential benefits and risks of treatment, including the most common side effects such as injection site reactions, and some serious side effects including allergic reactions that can sometimes be severe, eye problems, inflammation of your blood vessels, and joint aches and pain.

With DUPIXENT, my nasal polyps are under control.

When I wake up, I can breathe through my nose. Who would have thought that breathing easier through your nose would be such a relief?

I’m not sniffling all the time at work, and I’m not worried about bothering my coworkers. I don’t focus on my nasal polyps as much anymore.

With DUPIXENT, I’m able to DU MORE of the things I love like preparing a special dinner or creating the garden of my dreams!

So, if you’re struggling with nasal polyps, talk to your doctor and see if DUPIXENT may be right for you.

Thanks for watching!

VO:

Important Safety
Information and Indication

Do not use if you are allergic to dupilumab or to any of the ingredients in DUPIXENT®.

Before using DUPIXENT, tell your healthcare provider about all your medical conditions, including if you:

  • have eye problems.
  • have a parasitic (helminth) infection.
  • are scheduled to receive any vaccinations. You should not receive a “live vaccine” right before and during treatment with DUPIXENT.
  • are pregnant or plan to become pregnant. It is not known whether DUPIXENT will harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known whether DUPIXENT passes into your breast milk.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.

Especially tell your healthcare provider if you are taking oral, topical, or inhaled corticosteroid medicines or if you have CRSwNP and asthma and use an asthma medicine. Do not change or stop your corticosteroid medicine or other asthma medicine without talking to your healthcare provider. This may cause other symptoms that were controlled by the corticosteroid medicine or other asthma medicine to come back.

DUPIXENT can cause serious side effects, including:

  • Allergic reactions. DUPIXENT can cause allergic reactions that can sometimes be severe. Stop using DUPIXENT and tell your healthcare provider or get emergency help right away if you get any of the following signs or symptoms: breathing problems or wheezing, swelling of the face, lips, mouth, tongue, or throat, fainting, dizziness, feeling lightheaded, fast pulse, fever, hives, joint pain, general ill feeling, itching, skin rash, swollen lymph nodes, nausea or vomiting, or cramps in your stomach-area.
  • Eye problems. Tell your healthcare provider if you have any new or worsening eye problems, including eye pain or changes in vision, such as blurred vision. Your healthcare provider may send you to an ophthalmologist for an eye exam if needed.
  • Inflammation of your blood vessels. Rarely, this can happen in people with asthma who receive DUPIXENT. This may happen in people who also take a steroid medicine by mouth that is being stopped or the dose is being lowered. It is not known whether this is caused by DUPIXENT. Tell your healthcare provider right away if you have: rash, chest pain, worsening shortness of breath, or a feeling of pins and needles or numbness of your arms or legs, or persistent fever.
  • Joint aches and pain. Some people who use DUPIXENT have had trouble walking or moving due to their joint symptoms, and in some cases needed to be hospitalized. Tell your healthcare provider about any new or worsening joint symptoms. Your healthcare provider may stop DUPIXENT if you develop joint symptoms.

The most common side effects in patients with chronic rhinosinusitis with nasal polyposis include injection site reactions, eye and eyelid inflammation, including redness, swelling, and itching, sometimes with blurred vision, high count of a certain white blood cell (eosinophilia), trouble sleeping (insomnia), toothache, gastritis and joint pain (arthralgia).

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of DUPIXENT. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Use DUPIXENT exactly as prescribed by your healthcare provider. It’s an injection given under the skin (subcutaneous injection). Your healthcare provider will decide if you or your caregiver can inject DUPIXENT. Do not try to prepare and inject DUPIXENT until you or your caregiver have been trained by your healthcare provider.

Please see accompanying full Prescribing Information including Patient Information.

Indication

DUPIXENT is a prescription medicine used with other medicines for the maintenance treatment of chronic rhinosinusitis with nasal polyposis (CRSwNP) in adults whose disease is not controlled. It is not known if DUPIXENT is safe and effective in children with chronic rhinosinusitis with nasal polyposis under 18 years of age.

TAKING A BIOLOGIC

Kathy:

Hi, I’m Kathy.

When my doctor encouraged me to try a biologic treatment for my uncontrolled nasal polyps, I was hesitant.

I don’t know... There was something about the idea of a “biologic” that seemed weird to me. I didn’t understand what it was or how it would work inside my body.

I had tried multiple prescription treatments—steroids, pills, nasal sprays. I’d even had surgery. Those options made more sense to me.

A biologic was something different and unfamiliar.

Still, I knew I needed to control my nasal polyps. I talked to my doctor about biologics and did some research, and I eventually came around.

I learned that a biologic can target underlying sources of inflammation, like the kind that causes my nasal polyps.

I talked with my doctor, and he reassured me that he had other patients on biologic treatments who had seen positive results and thought I might as well.

That made me feel more at ease.

At the end of the day, I decided to move forward with adding a biologic treatment.

And, in my case, that treatment was DUPIXENT.

Before I started DUPIXENT, I told my doctor about all the medical conditions I had and medications I was taking.

My doctor and I talked about the potential benefits and risks of treatment, including the most common side effects such as injection site reactions, and some serious side effects including allergic reactions that can sometimes be severe, eye problems, inflammation of your blood vessels, and joint aches and pain.

KATHY:

I’m happy to say that with DUPIXENT my nasal polyps are under control.

Looking back, I wish I would have started treatment sooner!

My advice? Do your homework, talk to your doctor, and see if DUPIXENT is right for you.

Thanks for watching!

VO:

Important Safety
Information and Indication

Do not use if you are allergic to dupilumab or to any of the ingredients in DUPIXENT®.

Before using DUPIXENT, tell your healthcare provider about all your medical conditions, including if you:

  • have eye problems.
  • have a parasitic (helminth) infection.
  • are scheduled to receive any vaccinations. You should not receive a “live vaccine” right before and during treatment with DUPIXENT.
  • are pregnant or plan to become pregnant. It is not known whether DUPIXENT will harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known whether DUPIXENT passes into your breast milk.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.

Especially tell your healthcare provider if you are taking oral, topical, or inhaled corticosteroid medicines or if you have CRSwNP and asthma and use an asthma medicine. Do not change or stop your corticosteroid medicine or other asthma medicine without talking to your healthcare provider. This may cause other symptoms that were controlled by the corticosteroid medicine or other asthma medicine to come back.

DUPIXENT can cause serious side effects, including:

  • Allergic reactions. DUPIXENT can cause allergic reactions that can sometimes be severe. Stop using DUPIXENT and tell your healthcare provider or get emergency help right away if you get any of the following signs or symptoms: breathing problems or wheezing, swelling of the face, lips, mouth, tongue, or throat, fainting, dizziness, feeling lightheaded, fast pulse, fever, hives, joint pain, general ill feeling, itching, skin rash, swollen lymph nodes, nausea or vomiting, or cramps in your stomach-area.
  • Eye problems. Tell your healthcare provider if you have any new or worsening eye problems, including eye pain or changes in vision, such as blurred vision. Your healthcare provider may send you to an ophthalmologist for an eye exam if needed.
  • Inflammation of your blood vessels. Rarely, this can happen in people with asthma who receive DUPIXENT. This may happen in people who also take a steroid medicine by mouth that is being stopped or the dose is being lowered. It is not known whether this is caused by DUPIXENT. Tell your healthcare provider right away if you have: rash, chest pain, worsening shortness of breath, or a feeling of pins and needles or numbness of your arms or legs, or persistent fever.
  • Joint aches and pain. Some people who use DUPIXENT have had trouble walking or moving due to their joint symptoms, and in some cases needed to be hospitalized. Tell your healthcare provider about any new or worsening joint symptoms. Your healthcare provider may stop DUPIXENT if you develop joint symptoms.

The most common side effects in patients with chronic rhinosinusitis with nasal polyposis include injection site reactions, eye and eyelid inflammation, including redness, swelling, and itching, sometimes with blurred vision, high count of a certain white blood cell (eosinophilia), trouble sleeping (insomnia), toothache, gastritis and joint pain (arthralgia).

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of DUPIXENT. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Use DUPIXENT exactly as prescribed by your healthcare provider. It’s an injection given under the skin (subcutaneous injection). Your healthcare provider will decide if you or your caregiver can inject DUPIXENT. Do not try to prepare and inject DUPIXENT until you or your caregiver have been trained by your healthcare provider.

Please see accompanying full Prescribing Information including Patient Information.

Indication

DUPIXENT is a prescription medicine used with other medicines for the maintenance treatment of chronic rhinosinusitis with nasal polyposis (CRSwNP) in adults whose disease is not controlled. It is not known if DUPIXENT is safe and effective in children with chronic rhinosinusitis with nasal polyposis under 18 years of age.

MARTIN’S STORY

After years of struggling with CRSwNP symptoms, Martin elected to have surgery to treat his nasal
polyps. Unfortunately, the polyps returned just a few years later. See what happened when Martin was
presented with DUPIXENT as a treatment option.

AN ALTERNATIVE TO SURGERY

MARTIN:

I grew up in the Sacramento Valley. There’s a lot of agriculture here, and I remember my allergies and hay fever acting up all the time.

Getting through the day, sometimes, wasn’t so easy.

Some of the symptoms that I was experiencing were allergies, hay fever, stuffy nose, lots of sneezing.

MARTIN:

When I was in my 30s, my nasal issues changed, and they got a lot worse.

They started to have greater impacts on my life.

I experienced vertigo, I had nasal infections a little bit more frequently, and I even lost my smell.

MARTIN:

I decided to go see an ENT, and there, I was diagnosed with chronic rhinosinusitis with nasal polyposis.

We did a scan.

I was told that my entire nasal cavities were blocked.

MARTIN:

My doctor said that I had to have surgery to remove my nasal polyps, and that’s what I did.

Surprisingly, a few years later, my polyps came back.

So, I found a new ENT and I ended up having to have another surgery.

I wasn’t looking forward to a second surgery.

At this point, I’d already lost my sense of smell a few times.

And not being able to smell foods at different events was really hard.

My symptoms were really having an effect on me.

VO:

In a moment, you’ll hear more from Martin about his experience with uncontrolled chronic rhinosinusitis with nasal polyposis (CRSwNP) and treatment with DUPIXENT®(dupilumab).

DUPIXENT is an add-on treatment for people 18 years and older living with uncontrolled chronic rhinosinusitis with nasal polyposis (CRSwNP).

Important Safety Information

Do not use if you are allergic to dupilumabor to any of the ingredients in DUPIXENT®.

Please see additional Important SafetyInformation throughout this video and adjacent links for full Prescribing Information.

Individual results with DUPIXENT may vary.

MARTIN:

After everything I’d already been through, I was really excited when my doctor introduced me to DUPIXENT.

I was hesitant to try another medicine, but I was open to trying an option that was going to be an alternative to surgery.

MARTIN:

Before I started DUPIXENT, I told my doctor about all the medical conditions I had and medications I was taking.

My doctor and I talked about the potential benefits and risks of treatment, including the most common side effects such as injection site reactions, and some serious side effects including allergic reactions that can sometimes be severe, eye problems, inflammation of your blood vessels, and joint aches and pain.

MARTIN:

I liked the idea of taking an injectable medicine every other week.

I did my research and I decided to give it a try.

MARTIN:

After starting treatment with DUPIXENT, I went to see my healthcare team and they were impressed with my progress.

I was super excited that finally my nasal symptoms were under control.

This is my experience and yours might be different.

MARTIN:

I’m really glad I can breathe better through my nose!

Now, when I play steel drums, I’m driving around, traveling visiting friends, I can just really immerse myself in the experience.

I’m really happy with the team of doctors that got me to this point, and I’m moving forward!

There’s a lot for me on the horizon and in the future. I’m just enjoying it one day at a time, one breath at a time!

VO:

Important Safety
Information and Indication

Do not use if you are allergic to dupilumab or to any of the ingredients in DUPIXENT®.

Before using DUPIXENT, tell your healthcare provider about all your medical conditions, including if you:

  • have eye problems.
  • have a parasitic (helminth) infection.
  • are scheduled to receive any vaccinations. You should not receive a “live vaccine” right before and during treatment with DUPIXENT.
  • are pregnant or plan to become pregnant. It is not known whether DUPIXENT will harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known whether DUPIXENT passes into your breast milk.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.

Especially tell your healthcare provider if you are taking oral, topical, or inhaled corticosteroid medicines or if you have CRSwNP and asthma and use an asthma medicine. Do not change or stop your corticosteroid medicine or other asthma medicine without talking to your healthcare provider. This may cause other symptoms that were controlled by the corticosteroid medicine or other asthma medicine to come back.

DUPIXENT can cause serious side effects, including:

  • Allergic reactions. DUPIXENT can cause allergic reactions that can sometimes be severe. Stop using DUPIXENT and tell your healthcare provider or get emergency help right away if you get any of the following signs or symptoms: breathing problems or wheezing, swelling of the face, lips, mouth, tongue, or throat, fainting, dizziness, feeling lightheaded, fast pulse, fever, hives, joint pain, general ill feeling, itching, skin rash, swollen lymph nodes, nausea or vomiting, or cramps in your stomach-area.
  • Eye problems. Tell your healthcare provider if you have any new or worsening eye problems, including eye pain or changes in vision, such as blurred vision. Your healthcare provider may send you to an ophthalmologist for an eye exam if needed.
  • Inflammation of your blood vessels. Rarely, this can happen in people with asthma who receive DUPIXENT. This may happen in people who also take a steroid medicine by mouth that is being stopped or the dose is being lowered. It is not known whether this is caused by DUPIXENT. Tell your healthcare provider right away if you have: rash, chest pain, worsening shortness of breath, or a feeling of pins and needles or numbness of your arms or legs, or persistent fever.
  • Joint aches and pain. Some people who use DUPIXENT have had trouble walking or moving due to their joint symptoms, and in some cases needed to be hospitalized. Tell your healthcare provider about any new or worsening joint symptoms. Your healthcare provider may stop DUPIXENT if you develop joint symptoms.

The most common side effects in patients with chronic rhinosinusitis with nasal polyposis include injection site reactions, eye and eyelid inflammation, including redness, swelling, and itching, sometimes with blurred vision, high count of a certain white blood cell (eosinophilia), trouble sleeping (insomnia), toothache, gastritis and joint pain (arthralgia).

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of DUPIXENT. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Use DUPIXENT exactly as prescribed by your healthcare provider. It’s an injection given under the skin (subcutaneous injection). Your healthcare provider will decide if you or your caregiver can inject DUPIXENT. Do not try to prepare and inject DUPIXENT until you or your caregiver have been trained by your healthcare provider.

Please see accompanying full Prescribing Information including Patient Information.

Indication

DUPIXENT is a prescription medicine used with other medicines for the maintenance treatment of chronic rhinosinusitis with nasal polyposis (CRSwNP) in adults whose disease is not controlled. It is not known if DUPIXENT is safe and effective in children with chronic rhinosinusitis with nasal polyposis under 18 years of age.

MELINDA'S STORY

Living with CRSwNP hasn't been easy for Melinda. Common activities left her out of breath,
and the ability to smell things like fresh laundry and baked cookies was tough. See how
DUPIXENT helped her stop worrying about her symptoms and enjoy the things she loves.

THE IMPACT OF DUPIXENT

MELINDA:

Hi, I'm Melinda. For me, living with nasal polyps (also known as chronic rhinosinusitis with nasal polyposis) was not easy.

My nose was almost always stuffy, and I felt congested all of the time.

Walking up the stairs, doing simple yoga, or even just talking would often leave me out of breath.

I couldn’t smell everyday things like fresh-baked cookies or even clean laundry.

I was going through one treatment option after the next. Nasal steroids, sprays, even surgery. I was not getting the relief I was looking for. It was so frustrating!

Living with my nasal polyps was exhausting. It felt like they were controlling me when it should have been the other way around.

Then, one day, my doctor suggested we try adding DUPIXENT.

MELINDA:

Before I started DUPIXENT, I told my doctor about all the medical conditions I had and medications I was taking.

My doctor and I talked about the potential benefits and risks of treatment, including the most common side effects such as injection site reactions, and some serious side effects including allergic reactions that can sometimes be severe, eye problems, inflammation of your blood vessels, and joint aches and pain.

With DUPIXENT, I'm managing my nasal polyps, and I’m able to do more. I’m not as congested. I’m breathing more easily. And my ability to smell has really improved!

I’ll never forget the time I was slicing onions. I was cutting them, and then it hit me: My sense of smell is coming back! After that, I just wanted to do laundry and shampoo my carpets. Clean never smelled so good!

So, if your nasal polyps are not well-controlled, talk to your doctor and see if DUPIXENT might be right for you.

Thanks for watching!

VO:

Important Safety
Information and Indication

Do not use if you are allergic to dupilumab or to any of the ingredients in DUPIXENT®.

Before using DUPIXENT, tell your healthcare provider about all your medical conditions, including if you:

  • have eye problems.
  • have a parasitic (helminth) infection.
  • are scheduled to receive any vaccinations. You should not receive a “live vaccine” right before and during treatment with DUPIXENT.
  • are pregnant or plan to become pregnant. It is not known whether DUPIXENT will harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known whether DUPIXENT passes into your breast milk.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.

Especially tell your healthcare provider if you are taking oral, topical, or inhaled corticosteroid medicines or if you have CRSwNP and asthma and use an asthma medicine. Do not change or stop your corticosteroid medicine or other asthma medicine without talking to your healthcare provider. This may cause other symptoms that were controlled by the corticosteroid medicine or other asthma medicine to come back.

DUPIXENT can cause serious side effects, including:

  • Allergic reactions. DUPIXENT can cause allergic reactions that can sometimes be severe. Stop using DUPIXENT and tell your healthcare provider or get emergency help right away if you get any of the following signs or symptoms: breathing problems or wheezing, swelling of the face, lips, mouth, tongue, or throat, fainting, dizziness, feeling lightheaded, fast pulse, fever, hives, joint pain, general ill feeling, itching, skin rash, swollen lymph nodes, nausea or vomiting, or cramps in your stomach-area.
  • Eye problems. Tell your healthcare provider if you have any new or worsening eye problems, including eye pain or changes in vision, such as blurred vision. Your healthcare provider may send you to an ophthalmologist for an eye exam if needed.
  • Inflammation of your blood vessels. Rarely, this can happen in people with asthma who receive DUPIXENT. This may happen in people who also take a steroid medicine by mouth that is being stopped or the dose is being lowered. It is not known whether this is caused by DUPIXENT. Tell your healthcare provider right away if you have: rash, chest pain, worsening shortness of breath, or a feeling of pins and needles or numbness of your arms or legs, or persistent fever.
  • Joint aches and pain. Some people who use DUPIXENT have had trouble walking or moving due to their joint symptoms, and in some cases needed to be hospitalized. Tell your healthcare provider about any new or worsening joint symptoms. Your healthcare provider may stop DUPIXENT if you develop joint symptoms.

The most common side effects in patients with chronic rhinosinusitis with nasal polyposis include injection site reactions, eye and eyelid inflammation, including redness, swelling, and itching, sometimes with blurred vision, high count of a certain white blood cell (eosinophilia), trouble sleeping (insomnia), toothache, gastritis and joint pain (arthralgia).

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of DUPIXENT. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Use DUPIXENT exactly as prescribed by your healthcare provider. It’s an injection given under the skin (subcutaneous injection). Your healthcare provider will decide if you or your caregiver can inject DUPIXENT. Do not try to prepare and inject DUPIXENT until you or your caregiver have been trained by your healthcare provider.

Please see accompanying full Prescribing Information including Patient Information.

Indication

DUPIXENT is a prescription medicine used with other medicines for the maintenance treatment of chronic rhinosinusitis with nasal polyposis (CRSwNP) in adults whose disease is not controlled. It is not known if DUPIXENT is safe and effective in children with chronic rhinosinusitis with nasal polyposis under 18 years of age.

MY DECISION

MELINDA:

Hi, I'm Melinda. My ENT and I work together to manage my nasal polyps.

It’s been a good partnership. We communicate well. And he trusts me, and I trust him.

But when he first suggested adding DUPIXENT as a treatment option, I was like, "Really?"

We had tried a number of different treatment options in the past, and I had just had surgery to remove them.

I thought I was done. I was ready to move on.

My doctor said that even with surgery there was a possibility that my nasal polyps would come back because surgery doesn't address the underlying inflammation that causes them.

He explained that DUPIXENT is an add-on maintenance treatment and an alternative to surgery that helps block the source of that inflammation.

He also told me that other patients who previously had surgery experienced positive results with DUPIXENT, reducing the need for another surgery.

I went home, and I read up on DUPIXENT and thought about it. I really wanted to do what I could do to keep my nasal polyps under control.

So, I changed my mind.

For me, the decision to start treatment with DUPIXENT also came down to how much I trusted my doctor.

He felt this was the right option for me. I knew he cared. And it felt like we were making the decision together.

MELINDA:

Before I started DUPIXENT, I told my doctor about all the medical conditions I had and medications I was taking.

My doctor and I talked about the potential benefits and risks of treatment, including the most common side effects such as injection site reactions, and some serious side effects including allergic reactions that can sometimes be severe, eye problems, inflammation of your blood vessels, and joint aches and pain.

So, my advice is to make sure that you have a good and trusting relationship with your doctor, and if you’re struggling with nasal polyps, work together to see if DUPIXENT may be right for you.

Thanks for watching!

VO:

Important Safety
Information and Indication

Do not use if you are allergic to dupilumab or to any of the ingredients in DUPIXENT®.

Before using DUPIXENT, tell your healthcare provider about all your medical conditions, including if you:

  • have eye problems.
  • have a parasitic (helminth) infection.
  • are scheduled to receive any vaccinations. You should not receive a “live vaccine” right before and during treatment with DUPIXENT.
  • are pregnant or plan to become pregnant. It is not known whether DUPIXENT will harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known whether DUPIXENT passes into your breast milk.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.

Especially tell your healthcare provider if you are taking oral, topical, or inhaled corticosteroid medicines or if you have CRSwNP and asthma and use an asthma medicine. Do not change or stop your corticosteroid medicine or other asthma medicine without talking to your healthcare provider. This may cause other symptoms that were controlled by the corticosteroid medicine or other asthma medicine to come back.

DUPIXENT can cause serious side effects, including:

  • Allergic reactions. DUPIXENT can cause allergic reactions that can sometimes be severe. Stop using DUPIXENT and tell your healthcare provider or get emergency help right away if you get any of the following signs or symptoms: breathing problems or wheezing, swelling of the face, lips, mouth, tongue, or throat, fainting, dizziness, feeling lightheaded, fast pulse, fever, hives, joint pain, general ill feeling, itching, skin rash, swollen lymph nodes, nausea or vomiting, or cramps in your stomach-area.
  • Eye problems. Tell your healthcare provider if you have any new or worsening eye problems, including eye pain or changes in vision, such as blurred vision. Your healthcare provider may send you to an ophthalmologist for an eye exam if needed.
  • Inflammation of your blood vessels. Rarely, this can happen in people with asthma who receive DUPIXENT. This may happen in people who also take a steroid medicine by mouth that is being stopped or the dose is being lowered. It is not known whether this is caused by DUPIXENT. Tell your healthcare provider right away if you have: rash, chest pain, worsening shortness of breath, or a feeling of pins and needles or numbness of your arms or legs, or persistent fever.
  • Joint aches and pain. Some people who use DUPIXENT have had trouble walking or moving due to their joint symptoms, and in some cases needed to be hospitalized. Tell your healthcare provider about any new or worsening joint symptoms. Your healthcare provider may stop DUPIXENT if you develop joint symptoms.

The most common side effects in patients with chronic rhinosinusitis with nasal polyposis include injection site reactions, eye and eyelid inflammation, including redness, swelling, and itching, sometimes with blurred vision, high count of a certain white blood cell (eosinophilia), trouble sleeping (insomnia), toothache, gastritis and joint pain (arthralgia).

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of DUPIXENT. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Use DUPIXENT exactly as prescribed by your healthcare provider. It’s an injection given under the skin (subcutaneous injection). Your healthcare provider will decide if you or your caregiver can inject DUPIXENT. Do not try to prepare and inject DUPIXENT until you or your caregiver have been trained by your healthcare provider.

Please see accompanying full Prescribing Information including Patient Information.

Indication

DUPIXENT is a prescription medicine used with other medicines for the maintenance treatment of chronic rhinosinusitis with nasal polyposis (CRSwNP) in adults whose disease is not controlled. It is not known if DUPIXENT is safe and effective in children with chronic rhinosinusitis with nasal polyposis under 18 years of age.

SHARE YOUR STORY

Your experience with DUPIXENT is unique and yours to tell, and we want to know your story. It can inspire people going through similar experiences. If selected, you may be featured in print materials, on social media, or in videos.

Are you interested in sharing your journey with DUPIXENT?
If so, please call 1-844-DUPIXENT (1-844-387-4936), option 5.