How quickly can DUPIXENT improve sense of smell?

SINUS-52

UPSIT: Week 24 (key secondary endpoint). LSM difference between DUPIXENT 300 mg Q2W + INCS (n=295, pooled DUPIXENT arms) and placebo + INCS (n=153): 10.52 (95% CI: 8.98, 12.07).⁴

Loss of Smell score (results are descriptive, definitive conclusions cannot be made as this was a post hoc analysis; data prior to Week 24 were not multiplicity controlled); rapid improvement in patient-reported loss of smell was observed as early as Day 3.^6,a

Improvement in sense of smell was investigated in 2 measures: UPSIT score and daily Loss of Smell score.

^aLSM difference between DUPIXENT 300 mg Q2W + INCS (n=438) and placebo + INCS (n=286): -0.07 (95% CI: -0.12, -0.02).⁷

Week 24 in SINUS-52 (key secondary endpoint). LSM difference between DUPIXENT 300 mg Q2W + INCS (n=295, pooled arms) and placebo + INCS (n=153): -0.98 (95% CI: -1.15, -0.81) (-1.21 from a baseline score of 2.77 vs -0.23 from a baseline score of 2.72, respectively.⁴

Loss of Smell (LoS) score (range 0-3): reduced score indicates improvement.¹

University of Pennsylvania Smell Identification Test (UPSIT) score (range 0 to 40): higher score indicates improvement.

CI, confidence interval; INCS, intranasal corticosteroid; LSM, least squares mean; Q2W, once every 2 weeks.

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