DUPIXENT is the first and only dual inhibitor of IL-4 and IL-13 signaling, addressing type 2 inflammation that contributes to CRSwNP.^1-3,a DUPIXENT is not a steroid.¹ DUPIXENT inhibits IL-4 and IL-13 cytokine-induced inflammatory responses and cell signaling.^1-3,a These cytokines contribute to IgE production, mast cell activation, eosinophil activation and trafficking, epithelial barrier dysfunction, and Th2 cell activation.^1-3

^aThe mechanism of dupilumab action has not been definitively established.¹

View the unique Mechanism of Action of DUPIXENT