DUPIXENT is the first and only dual inhibitor of IL-4 and IL-13 signaling, addressing type 2 inflammation that contributes to CRSwNP. DUPIXENT is not a steroid. DUPIXENT inhibits IL-4 and IL-13 cytokine-induced inflammatory responses and cell signaling that contribute to IgE production, mast cell activation, eosinophil activation and trafficking, epithelial barrier dysfunction, and Th2 cell activation.1,2

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