VENTURE (12+ years), TRAVERSE OLE (12+ years)

86% of patients reduced or eliminated their OCS dose at Week 24 with DUPIXENT 300 mg Q2W + SOC (n=103) vs 68% with placebo + SOC (n=107) (No biomarker requirement, ITT population, VENTURE).13

A 70% significant reduction in OCS dose (median 100%) from baseline was observed at Week 24 with DUPIXENT 300 mg Q2W + SOC (n=103) (95% CI: 60%, 80%) vs 42% (median 50%) with placebo + SOC (n=107) (primary endpoint).1

89% reduction in OCS dose at Week 96 (TRAVERSE OLE).14

From PSBL for patients who received DUPIXENT 300 mg Q2W + SOC in the parent study and continued on DUPIXENT during the open-label extension study (n=19).14,d

By Week 96 in TRAVERSE OLE, a 79% reduction in exacerbations and a 250 mL improvement in lung function from PSBL were observed.9,14,e

In addition, 79% of patients from VENTURE eliminated their OCS dose at Week 96 in TRAVERSE OLE (secondary endpoint).9,14

TRAVERSE OLE results are descriptive. Definitive conclusions cannot be made.

Data were not multiplicity controlled, and there are limitations associated with open-label study design, including lack of comparator arm, decreasing sample size, and potential continued involvement of responders and attritions of nonresponders.

dRate of unadjusted exacerbations through Week 96 in the DUPIXENT/DUPIXENT group (n=90) was 0.39 from a mean of 1.90 exacerbations in the year prior to VENTURE.9,14

e250 mL improvement in FEV1 at Week 96 of TRAVERSE from VENTURE baseline in the DUPIXENT/DUPIXENT group (n=28) vs 360 mL in the placebo/DUPIXENT group (n=32).14

fOCS reduction was at investigators’ discretion.14